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Idris AM, Assubaie FN, Sultan SM. Experimental design optimization of a sequential injection method for promazine assay in bulk and pharmaceutical formulations. J Autom Methods Manag Chem. 2007;2007:32470doi: 10.1155/2007/32470.
Idris, A. M., Assubaie, F. N., & Sultan, S. M. (2007). Experimental design optimization of a sequential injection method for promazine assay in bulk and pharmaceutical formulations. Journal of automated methods & management in chemistry, 200732470. https://doi.org/10.1155/2007/32470
Idris, Abubakr M, et al. "Experimental design optimization of a sequential injection method for promazine assay in bulk and pharmaceutical formulations." Journal of automated methods & management in chemistry vol. 2007 (2007): 32470. doi: https://doi.org/10.1155/2007/32470
Idris AM, Assubaie FN, Sultan SM. Experimental design optimization of a sequential injection method for promazine assay in bulk and pharmaceutical formulations. J Autom Methods Manag Chem. 2007;2007:32470. doi: 10.1155/2007/32470. PMID: 18350124; PMCID: PMC2266988.
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J Autom Methods Manag Chem. 2007;2007:32470. doi: 10.1155/2007/32470.

Experimental design optimization of a sequential injection method for promazine assay in bulk and pharmaceutical formulations.

Journal of automated methods & management in chemistry

Abubakr M Idris, Fahad N Assubaie, Salah M Sultan

Affiliations

  1. Department of Chemistry, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia.

PMID: 18350124 PMCID: PMC2266988 DOI: 10.1155/2007/32470

Abstract

Experimental design optimization approach was utilized to develop a sequential injection analysis (SIA) method for promazine assay in bulk and pharmaceutical formulations. The method was based on the oxidation of promazine by Ce(IV) in sulfuric acidic media resulting in a spectrophotometrically detectable species at 512 nm. A 3(3) full factorial design and response surface methods were applied to optimize experimental conditions potentially controlling the analysis. The optimum conditions obtained were 1.0 x 10(-4) M sulphuric acid, 0.01 M Ce(IV), and 10 muL/s flow rate. Good analytical parameters were obtained including range of linearity 1-150 mug/mL, linearity with correlation coefficient 0.9997, accuracy with mean recovery 98.2%, repeatability with RSD 1.4% (n = 7 consequent injections), intermediate precision with RSD 2.1% (n = 5 runs over a week), limits of detection 0.34 mug/mL, limits of quantification 0.93 mug/mL, and sampling frequency 23 samples/h. The obtained results were realized by the British Pharmacopoeia method and comparable results were obtained. The provided SIA method enjoys the advantages of the technique with respect to rapidity, reagent/sample saving, and safety in solution handling and to the environment.

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