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Curr Treat Options Cardiovasc Med. 2008 Feb;10(1):39-48. doi: 10.1007/s11936-008-0005-1.

Treatment options for patients with coronary artery disease identified as high risk by T-wave alternans testing.

Current treatment options in cardiovascular medicine

Kapil Kumar, Kevin F Kwaku, Richard L Verrier

Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Room 223, Boston, MA 02115, USA.

PMID: 18325306 DOI: 10.1007/s11936-008-0005-1

Abstract

Risk stratification for primary prevention of sudden cardiac death (SCD) remains a major challenge in cardiology. The utility of T-wave alternans (TWA) as a marker of risk of life-threatening ventricular tachycardia and fibrillation is supported by two decades of basic and clinical research. Both frequency- and time-domain methods have been developed, validated, and made available in clinical practice. A principal application of TWA testing has been to improve assessment of patients with depressed left ventricular ejection fraction (EF;

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