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Manouras A, Giannopoulos P, Toufektzian L, et al. Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. J Med Case Rep. 2008;2:133doi: 10.1186/1752-1947-2-133.
Manouras, A., Giannopoulos, P., Toufektzian, L., Markogiannakis, H., Lagoudianakis, E. E., Papadima, A., Papanikolaou, D., Filis, K., & Kekis, P. (2008). Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. Journal of medical case reports, 2133. https://doi.org/10.1186/1752-1947-2-133
Manouras, Andreas, et al. "Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report." Journal of medical case reports vol. 2 (2008): 133. doi: https://doi.org/10.1186/1752-1947-2-133
Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis EE, Papadima A, Papanikolaou D, Filis K, Kekis P. Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. J Med Case Rep. 2008 Apr 29;2:133. doi: 10.1186/1752-1947-2-133. PMID: 18445294; PMCID: PMC2387157.
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J Med Case Rep. 2008 Apr 29;2:133. doi: 10.1186/1752-1947-2-133.

Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report.

Journal of medical case reports

Andreas Manouras, Panagiotis Giannopoulos, Levon Toufektzian, Haridimos Markogiannakis, Emmanuel E Lagoudianakis, Artemisia Papadima, Dimitrios Papanikolaou, Konstantinos Filis, Panagiotis Kekis

Affiliations

  1. 1st Department of Propaedeutic Surgery, Hippokrateion Hospital, Athens Medical School, University of Athens, Athens, Greece. [email protected]

PMID: 18445294 PMCID: PMC2387157 DOI: 10.1186/1752-1947-2-133

Abstract

INTRODUCTION: Primary splenic angiosarcoma is a rare neoplasm of vascular origin carrying a very poor prognosis, partly due to its high metastatic potential. This disease presents frequently with splenic rupture and hemorrhage. We report the case of a 17-year-old woman who presented with rupture of a primary splenic angiosarcoma.

CASE PRESENTATION: The patient presented with diffuse abdominal pain and distention. Clinical examination revealed severe tenderness in the left upper abdominal quadrant, a palpable abdominal mass, and hemodynamic instability with a systolic arterial blood pressure of 75 mmHg and heart rate of 135 beats per minute. Blood tests revealed anemia (hemoglobin 7.0 g/dl) and thrombocytopenia (platelets 70 x 109/liter). After initial fluid resuscitation and stabilization, abdominal ultrasound and computed tomography were performed, revealing a large quantity of intraperitoneal free fluid, an enlarged spleen, and a heterogeneous low-density signal within the splenic parenchyma, which showed varying degrees of contrast enhancement. At laparotomy a huge (weight 1530 g, diameter 19 cm) actively bleeding spleen was identified and splenectomy was performed. Histopathology showed a primary splenic angiosarcoma. After an uneventful recovery, the patient was discharged on the sixth postoperative day.

CONCLUSION: Primary splenic angiosarcoma is rare. Although this malignancy is usually encountered in advanced age, there have been a few reported cases among younger patients. The case reported here presented with splenic rupture, was treated by laparotomy and splenectomy, and the patient is disease free 16 months after surgery.

References

  1. Int Surg. 1980 Jul-Aug;65(4):369-73 - PubMed
  2. JAMA. 1984 Dec 7;252(21):2959-60 - PubMed
  3. J Surg Oncol. 2005 Dec 15;92(4):312-6 - PubMed
  4. J Surg Oncol. 1996 Mar;61(3):170-6 - PubMed
  5. Am J Surg Pathol. 1993 Oct;17(10):959-70 - PubMed
  6. South Med J. 1995 Aug;88(8):873-5 - PubMed
  7. J Okla State Med Assoc. 1990 May;83(5):211-3 - PubMed
  8. Surg Today. 1993;23(4):370-4 - PubMed
  9. Acta Chir Belg. 2004 Apr;104(2):217-20 - PubMed
  10. Abdom Imaging. 1999 Mar-Apr;24(2):185-7 - PubMed
  11. Mod Pathol. 2000 Sep;13(9):978-87 - PubMed
  12. Ter Arkh. 1990;62(9):124-6 - PubMed

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