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Coopersmith CM, Lowell JA, Hassan A, et al. Hepatocellular carcinoma in a patient with focal nodular hyperplasia. HPB (Oxford). 2002;4(3):135-8doi: 10.1080/136518202760388046.
Coopersmith, C. M., Lowell, J. A., Hassan, A., & Howard, T. K. (2002). Hepatocellular carcinoma in a patient with focal nodular hyperplasia. HPB : the official journal of the International Hepato Pancreato Biliary Association, 4(3), 135-8. https://doi.org/10.1080/136518202760388046
Coopersmith, Craig M, et al. "Hepatocellular carcinoma in a patient with focal nodular hyperplasia." HPB : the official journal of the International Hepato Pancreato Biliary Association vol. 4,3 (2002): 135-8. doi: https://doi.org/10.1080/136518202760388046
Coopersmith CM, Lowell JA, Hassan A, Howard TK. Hepatocellular carcinoma in a patient with focal nodular hyperplasia. HPB (Oxford). 2002;4(3):135-8. doi: 10.1080/136518202760388046. PMID: 18332941; PMCID: PMC2020544.
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HPB (Oxford). 2002;4(3):135-8. doi: 10.1080/136518202760388046.

Hepatocellular carcinoma in a patient with focal nodular hyperplasia.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Craig M Coopersmith, Jeffrey A Lowell, Anjum Hassan, Todd K Howard

Affiliations

  1. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

PMID: 18332941 PMCID: PMC2020544 DOI: 10.1080/136518202760388046

Abstract

BACKGROUND: Focal nodular hyperplasia is an uncommon liver tumour that typically requires no therapeutic intervention.

CASE OUTLINE: A 43-year-old woman with a 20-year history of oral contraceptive use presented with symptomatic bilateral liver masses. Biopsy revealed hepatocellular carcinoma in the right hemiliver and focal nodular hyperplasia in the left hemiliver. At operation,t he patient was noted to have multiple liver nodules bilaterally, and all intraoperative biopsies were consistent with focal nodular hyperplasia including a biopsy taken from the region that demonstrated carcinoma preoperatively. Because of the earlier biopsy results and the patient's preoperative symptoms, a right hemihepatectomy was performed. Final pathology revealed hepatocellular carcinoma directly adjacent to an area of focal nodular hyperplasia, as well as multiple other areas of hyperplastic liver tumour.

DISCUSSION: Although focal nodular hyperplasia is believed to be benign, few studies have followed patients with this tumour beyond three years. Longer-term follow-up studies are needed to determine the natural history of focal nodular hyperplasia, potentially focussing on a subset of patients with either diffuse tumours or prolonged oral contraceptive use.

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