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HPB (Oxford). 2006;8(2):153-5. doi: 10.1080/13651820600686998.

Idiopathic fibrosing pancreatitis associated with ulcerative colitis.

HPB : the official journal of the International Hepato Pancreato Biliary Association

E Nve, D Ribé, J Navinés, M J Villanueva, G Franch, A Torrecilla, J Blay, J M Badia

Affiliations

  1. Department of Surgery, Hospital General de Granollers, Barcelona, Spain.

PMID: 18333266 PMCID: PMC2131411 DOI: 10.1080/13651820600686998

Abstract

Idiopathic fibrosing pancreatitis has been associated with Sjögren's syndrome, primary biliary cirrhosis and primary sclerosing cholangitis. This condition frequently develops in childhood and youth, and has also been related to ulcerative colitis and pericholangitis. Pancreatic complications have been rarely described as systemic complications of ulcerative colitis. A 25-year-old man presented with epigastric pain and jaundice. Abdominal ultrasonography, computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) revealed a diffuse enlargement of the pancreas, filiform distal stenosis of the common bile duct and intrahepatic bile ducts, and pancreatic duct dilatation. At operation, a rock-hard and nodular pancreas was noted. Cholecystectomy and Roux-en-Y hepaticojejunostomy, with an access loop, was successfully performed. Idiopathic fibrosing pancreatitis should be considered in young patients with obstructive jaundice, especially those affected with chronic inflammatory or autoimmune diseases. Glucocorticoid therapy would be the first-line treatment, although many patients require operation.

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