Display options
Cite
Demling RH, Waterhouse B. The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus. J Burns Wounds. 2007;7:e8
Demling, R. H., & Waterhouse, B. (2007). The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus. Journal of burns and wounds, 7e8.
Demling, Robert H, and Waterhouse, Barbara. "The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus." Journal of burns and wounds vol. 7 (2007): e8.
Demling RH, Waterhouse B. The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus. J Burns Wounds. 2007 Nov 16;7:e8. PMID: 18091985; PMCID: PMC2104747.
Copy Download .nbib Format: NLM
Share it on

J Burns Wounds. 2007 Nov 16;7:e8.

The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillin-resistant Staphylococcus aureus.

Journal of burns and wounds

Robert H Demling, Barbara Waterhouse

Affiliations

  1. Brigham and Women's Hospital, Burn and Trauma Center, Boston, MA, USA. [email protected]

PMID: 18091985 PMCID: PMC2104747

Abstract

UNLABELLED: Methicillin-resistant Staphylococcus aureus (MRSA) has become a leading cause of colonization and infection in both acute and chronic soft-tissue wounds.

OBJECTIVE: Our objective is to define this current epidemic problem caused by both community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA), focusing on the similarities and differences between these 2 isolates as well as the impact on wound management decisions.

METHODS: Methods used include a literature review on the growth of the current MRSA problem and its International scope. In addition, a current up-to-date assessment had been made of the problem and the current approach to management of MRSA in acute soft-tissue and chronic wounds. Burns are not discussed because this injury usually does not fit either categories and is managed quite uniquely.

RESULTS: Results included the following: (1) There are very distinct properties of CA-MRSA and HA-MRSA, which must be considered for acute and chronic wound care. Management of both requires rigorous barrier precaution techniques to avoid cross-contamination. The presence of MRSA as a carrier state increases the risk of both a systemic and local wound infection in the carrier. There are large and increasing reservoirs of CA-MRSA and HA-MRSA worldwide leading to more bacteremias and wound problems. Topical antimicrobial therapy has not been addressed in managing MRSA in acute and chronic wounds.

CONCLUSION: Conclusions include the fact that both HA-MRSA and CA-MRSA wound infections are rapidly increasing, especially with CA-MRSA. This high incidence requires appropriate wound prediction and management decisions as well as attempts to avoid further cross-contamination and reservoir growth. Topical antimicrobial therapy would seem to be an important component in controlling this tremendous problem. Yet this topic has yet to be adequately addressed.

References

  1. J Burn Care Rehabil. 1988 Nov-Dec;9(6):610-2 - PubMed
  2. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5620-5 - PubMed
  3. WMJ. 2006 Jan;105(1):52-7 - PubMed
  4. Ann Pharmacother. 2007 Jan;41(1):13-20 - PubMed
  5. Am J Med. 1993 Apr;94(4):371-8 - PubMed
  6. Ann Intern Med. 2006 Mar 7;144(5):309-17 - PubMed
  7. J Wound Care. 2006 Mar;15(3):97-100 - PubMed
  8. J Foot Ankle Surg. 2000 Jul-Aug;39(4):253-7 - PubMed
  9. Clin Infect Dis. 2003 Dec 1;37(11):1453-60 - PubMed
  10. J Wound Care. 2006 Jul;15(7):285-90 - PubMed
  11. Infect Control Hosp Epidemiol. 2006 Jun;27(6):581-5 - PubMed
  12. Curr Opin Infect Dis. 2004 Aug;17(4):317-22 - PubMed
  13. Clin Infect Dis. 2003 Jan 1;36(1):53-9 - PubMed
  14. Int Angiol. 2006 Jun;25(2):204-8 - PubMed
  15. Diabet Med. 2004 Jul;21(7):710-5 - PubMed
  16. J Wound Care. 2005 Oct;14(9):411-9 - PubMed
  17. J Antimicrob Chemother. 2004 Mar;53(3):474-9 - PubMed
  18. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9865-70 - PubMed
  19. Am J Surg. 1998 Aug;176(2A Suppl):5S-10S - PubMed
  20. Diabetes Metab Res Rev. 2004 May-Jun;20 Suppl 1:S56-64 - PubMed
  21. J Infect. 2007 May;54(5):439-45 - PubMed
  22. Microb Drug Resist. 2000 Fall;6(3):253-8 - PubMed
  23. Int Wound J. 2005 Mar;2(1):64-73 - PubMed
  24. N Engl J Med. 2006 Aug 17;355(7):724-7 - PubMed
  25. J Bone Joint Surg Br. 2006 Jun;88(6):812-7 - PubMed
  26. Clin Infect Dis. 2007 Mar 15;44(6):777-84 - PubMed
  27. Ann Dermatol Venereol. 2002 Jan;129(1 Pt 1):27-9 - PubMed
  28. JAMA. 1998 Feb 25;279(8):593-8 - PubMed
  29. Clin Microbiol Infect. 2000 Feb;6(2):59-63 - PubMed
  30. Ann Emerg Med. 2005 Mar;45(3):311-20 - PubMed
  31. Lancet. 2002 May 25;359(9320):1819-27 - PubMed
  32. Int J Antimicrob Agents. 2005 Dec;26(6):442-8 - PubMed
  33. Clin Infect Dis. 2006 Mar 1;42(5):647-56 - PubMed
  34. J Hosp Infect. 2001 Aug;48 Suppl A:S9-14 - PubMed
  35. Diabet Med. 2003 Feb;20(2):159-61 - PubMed
  36. J Infect Dis. 2006 Jan 15;193(2):172-9 - PubMed
  37. Emerg Infect Dis. 2003 Aug;9(8):978-84 - PubMed
  38. J Hosp Infect. 2006 May;63 Suppl 1:S1-44 - PubMed
  39. Infect Control Hosp Epidemiol. 2005 Jul;26(7):662-7 - PubMed
  40. N Engl J Med. 2006 Aug 17;355(7):666-74 - PubMed
  41. Infect Control Hosp Epidemiol. 2006 Oct;27(10):1032-40 - PubMed
  42. N Engl J Med. 1998 Aug 20;339(8):520-32 - PubMed
  43. Commun Dis Public Health. 2000 Dec;3(4):288-90 - PubMed
  44. J Hosp Infect. 2006 Nov;64(3):251-6 - PubMed
  45. Diabetes Metab Res Rev. 2004 May-Jun;20 Suppl 1:S68-77 - PubMed
  46. J Clin Microbiol. 1999 Sep;37(9):2798-803 - PubMed
  47. J Clin Microbiol. 2003 May;41(5):2027-32 - PubMed
  48. N Engl J Med. 1968 Aug 29;279(9):441-8 - PubMed
  49. Burns. 1999 Nov;25(7):640-4 - PubMed
  50. J Wound Care. 2006 May;15(5):199-206 - PubMed
  51. Clin Microbiol Infect. 2006 Feb;12(2):186-9 - PubMed
  52. J Antimicrob Chemother. 2006 Jun;57(6):1122-7 - PubMed
  53. J Hosp Infect. 2001 Feb;47(2):98-103 - PubMed
  54. Clin Infect Dis. 2004 Sep 15;39(6):776-82 - PubMed
  55. Infect Control Hosp Epidemiol. 2000 Jul;21(7):459-64 - PubMed
  56. Antimicrob Agents Chemother. 1993 Jan;37(1):32-8 - PubMed
  57. Int J Antimicrob Agents. 2000 Jul;15(2):91-101 - PubMed
  58. J Am Geriatr Soc. 1992 Mar;40(3):213-7 - PubMed
  59. Ostomy Wound Manage. 2006 Aug;52(8):26-58 - PubMed
  60. Ann Fam Med. 2006 Mar-Apr;4(2):132-7 - PubMed
  61. Clin Microbiol Infect. 2007 Apr;13(4):351-3 - PubMed
  62. J Dtsch Dermatol Ges. 2005 Apr;3(4):256-62 - PubMed
  63. Emerg Infect Dis. 2004 Sep;10(9):1627-34 - PubMed
  64. Am J Epidemiol. 1996 Mar 1;143(5):496-504 - PubMed
  65. Int Wound J. 2005 Dec;2(4):348-56 - PubMed

Publication Types