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Trynda-Lemiesz L, Luczkowski M. Impact of potential blockers on Ru(III) complex binding to human serum albumin. Bioinorg Chem Appl. 2003;141-50doi: 10.1155/S1565363303000116.
Trynda-Lemiesz, L., & Luczkowski, M. (2003). Impact of potential blockers on Ru(III) complex binding to human serum albumin. Bioinorganic chemistry and applications, 141-50. https://doi.org/10.1155/S1565363303000116
Trynda-Lemiesz, Lilianna, and Luczkowski, Marek. "Impact of potential blockers on Ru(III) complex binding to human serum albumin." Bioinorganic chemistry and applications vol. (2003): 141-50. doi: https://doi.org/10.1155/S1565363303000116
Trynda-Lemiesz L, Luczkowski M. Impact of potential blockers on Ru(III) complex binding to human serum albumin. Bioinorg Chem Appl. 2003;141-50. doi: 10.1155/S1565363303000116. PMID: 18365049; PMCID: PMC2267051.
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Bioinorg Chem Appl. 2003;141-50. doi: 10.1155/S1565363303000116.

Impact of potential blockers on Ru(III) complex binding to human serum albumin.

Bioinorganic chemistry and applications

Lilianna Trynda-Lemiesz, Marek Luczkowski

Affiliations

  1. Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw 50-383, Poland. [email protected]

PMID: 18365049 PMCID: PMC2267051 DOI: 10.1155/S1565363303000116

Abstract

The effects of aspirin, vitamin B(12) and warfarin as potential blockers of the ruthenium binding sites in HSA were investigated through UV/visible, circular dichroism (CD), fluorescence spectroscopy and the inductively coupled plasma-atomic emission spectroscopy ICP(AES). The studies on the interactions of several biologically relevant molecules with HSA have shown that drugs like aspirin or warfarin may strongly influence the interaction of serum protein with anticancer drugs. It can derive from the influence of the drug on protein conformation or binding close to binding site of anticancer drug. Aspirin, vitB(12) and warfarin bind to IIA subdomain leading to partial blocking of the ruthenium binding site in HSA.

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