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Lakkis N, Tsyboulev V, Gibson CM, et al. Outcome of patients with acute coronary syndrome admitted to hospitals with or without onsite cardiac catheterization laboratory: a TACTICS-TIMI 18 substudy. Crit Pathw Cardiol. 2002;1(4):232-7doi: 10.1097/00132577-200212000-00005.
Lakkis, N., Tsyboulev, V., Gibson, C. M., Murphy, S. A., Weintraub, W. S., DiBattiste, P. M., Cannon, C. P. (2002). Outcome of patients with acute coronary syndrome admitted to hospitals with or without onsite cardiac catheterization laboratory: a TACTICS-TIMI 18 substudy. Critical pathways in cardiology, 1(4), 232-7. https://doi.org/10.1097/00132577-200212000-00005
Lakkis, Nasser, et al. "Outcome of patients with acute coronary syndrome admitted to hospitals with or without onsite cardiac catheterization laboratory: a TACTICS-TIMI 18 substudy." Critical pathways in cardiology vol. 1,4 (2002): 232-7. doi: https://doi.org/10.1097/00132577-200212000-00005
Lakkis N, Tsyboulev V, Gibson CM, Murphy SA, Weintraub WS, DiBattiste PM, Cannon CP. Outcome of patients with acute coronary syndrome admitted to hospitals with or without onsite cardiac catheterization laboratory: a TACTICS-TIMI 18 substudy. Crit Pathw Cardiol. 2002 Dec;1(4):232-7. doi: 10.1097/00132577-200212000-00005. PMID: 18340309.
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Crit Pathw Cardiol. 2002 Dec;1(4):232-7. doi: 10.1097/00132577-200212000-00005.

Outcome of patients with acute coronary syndrome admitted to hospitals with or without onsite cardiac catheterization laboratory: a TACTICS-TIMI 18 substudy.

Critical pathways in cardiology

Nasser Lakkis, Valeri Tsyboulev, C Michael Gibson, Sabina A Murphy, William S Weintraub, Peter M DiBattiste, Christopher P Cannon,

Affiliations

  1. Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. [email protected]

PMID: 18340309 DOI: 10.1097/00132577-200212000-00005

Abstract

In the TACTICS-TIMI-18 trial, patients with acute coronary syndrome were treated with aspirin, heparin, and tirofiban and were randomized to an invasive strategy with routine catheterization or to a conservative strategy with catheterization (only if the patient had objective evidence of ischemia). Eighty-two of 2,220 patients were treated in 13 peripheral hospitals without an onsite catheterization laboratory. Tirofiban was administered to the peripheral hospital group (which was treated invasively) for 28.4 hours before coronary angiography, compared with 20.6 hours in the tertiary center group (P = 0.01). There is a similar trend in outcomes with benefit of invasive therapy among patients treated in peripheral and tertiary hospitals, without increase risk of major bleeding.

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