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Hemsell DL, Wendel GD, Hemsell PG, et al. Inpatient treatment for uncomplicated and complicated acute pelvic inflammatory disease: ampicillin/sulbactam vs. Cefoxitin. Infect Dis Obstet Gynecol. 1993;1(3):123-9doi: 10.1155/S1064744993000286.
Hemsell, D. L., Wendel, G. D., Hemsell, P. G., Heard, M. L., & Nobles, B. J. (1993). Inpatient treatment for uncomplicated and complicated acute pelvic inflammatory disease: ampicillin/sulbactam vs. Cefoxitin. Infectious diseases in obstetrics and gynecology, 1(3), 123-9. https://doi.org/10.1155/S1064744993000286
Hemsell, D L, et al. "Inpatient treatment for uncomplicated and complicated acute pelvic inflammatory disease: ampicillin/sulbactam vs. Cefoxitin." Infectious diseases in obstetrics and gynecology vol. 1,3 (1993): 123-9. doi: https://doi.org/10.1155/S1064744993000286
Hemsell DL, Wendel GD, Hemsell PG, Heard ML, Nobles BJ. Inpatient treatment for uncomplicated and complicated acute pelvic inflammatory disease: ampicillin/sulbactam vs. Cefoxitin. Infect Dis Obstet Gynecol. 1993;1(3):123-9. doi: 10.1155/S1064744993000286. PMID: 18475331; PMCID: PMC2364305.
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Infect Dis Obstet Gynecol. 1993;1(3):123-9. doi: 10.1155/S1064744993000286.

Inpatient treatment for uncomplicated and complicated acute pelvic inflammatory disease: ampicillin/sulbactam vs. Cefoxitin.

Infectious diseases in obstetrics and gynecology

D L Hemsell, G D Wendel, P G Hemsell, M L Heard, B J Nobles

Affiliations

  1. Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center at Dallas and Parkland Memorial Hospital, Dallas, TX 75235-9032, USA.

PMID: 18475331 PMCID: PMC2364305 DOI: 10.1155/S1064744993000286

Abstract

OBJECTIVE: Ampicillin plus sulbactam, an irreversible beta-lactamase inhibitor, was compared to cefoxitin in the treatment of women with acute pelvic inflammatory disease (PID) with and without inflammatory mass(es).

METHODS: Participation in an open, prospective, randomized clinical trial was offered to all women given the clinical diagnosis of acute PID who required inpatient therapy. Neisseria gonorrhoeae and Chlamydia trachomatis were sought in cervical and endometrial samples and aerobic and anaerobic species were sought in endometrial samples prior to treatment initiation. Treatment was given on at least 4 days and until women were afebrile for at least 48 h. Daily examinations were performed to assess response to therapy and safety. Only women in whom C. trachomatis was identified were discharged from the hospital on oral doxycycline to be taken for 10-14 days.

RESULTS: One hundred twenty-four women were evaluated for safety; 117 (94%) were evaluated for efficacy. Demographic characteristics were similar for women in each treatment group. N. gonorrhoeae was recovered from 59% and C. trachomatis was recovered from 42% of study subjects. Inflammatory masses were identified in 35/76 (46%) women given ampicillin/sulbactam and 17/41 (41%) women given cefoxitin. Ampicillin/sulbactam cured 75 ,of 76 women (98.7%) [95% confidence interval (CI) 92.9-100.0%] and cefoxitin cured 37 of,41,omen (90.2%) (95% CI 76.9-97.3%) in that treatment regimen.

CONCLUSIONS: Overall ampicillin/sulbactam was more effective (P = 0.05) than cefoxitin, due to superior efficacy in infection complicated by inflammatory mass(es).35/35 vs. 12/17 cured; P = 0.007).

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