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Lambert H, Collazo I, Steinleitner A. IL-7 and IL-8 inhibit gamete interaction in the zona-free hamster egg sperm penetration assay. Mediators Inflamm. 1992;1(1):67-9doi: 10.1155/S0962935192000139.
Lambert, H., Collazo, I., & Steinleitner, A. (1992). IL-7 and IL-8 inhibit gamete interaction in the zona-free hamster egg sperm penetration assay. Mediators of inflammation, 1(1), 67-9. https://doi.org/10.1155/S0962935192000139
Lambert, H, et al. "IL-7 and IL-8 inhibit gamete interaction in the zona-free hamster egg sperm penetration assay." Mediators of inflammation vol. 1,1 (1992): 67-9. doi: https://doi.org/10.1155/S0962935192000139
Lambert H, Collazo I, Steinleitner A. IL-7 and IL-8 inhibit gamete interaction in the zona-free hamster egg sperm penetration assay. Mediators Inflamm. 1992;1(1):67-9. doi: 10.1155/S0962935192000139. PMID: 18475444; PMCID: PMC2365311.
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Mediators Inflamm. 1992;1(1):67-9. doi: 10.1155/S0962935192000139.

IL-7 and IL-8 inhibit gamete interaction in the zona-free hamster egg sperm penetration assay.

Mediators of inflammation

H Lambert, I Collazo, A Steinleitner

Affiliations

  1. Department of Obstetrics and Gynecology Mount Sinai Medical Center Miami Beach FL USA.

PMID: 18475444 PMCID: PMC2365311 DOI: 10.1155/S0962935192000139

Abstract

Current thought in reproductive endocrinology suggests hat endometriosis-associated subfertility may be the result of an adverse influence of activated immunocompetent cells on fertilization and embryo development. Inflammatory ediators such as interleukin-1 and tumour necrosis actor have been implicated in the pathophysiology of this process. The purpose of this study was to assess the effect of two recently characterized cytokines, interleukin-7 (IL-7 ) and interleukin-8 (IL-8), on gamete interaction in the perm penetration assay (SPA). Donor sperm were preincubated or 4 h with 0.5, 5, 50, or 500 ng ml(-1) of human ecombinant IL-7 or IL-8. Sperm penetration was determined by an experienced gametologist by the presence of decondensed sperm heads or pronuclei formation. A dose-dependent inhibition of gamete interaction was observed following coincubation with either IL-7 or IL-8. These data offer the possibility that IL-7 and IL-8 may play a role in the pathogenesis of immunocompetent cell-associated subfertility.

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