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Toh H, Urade Y, Tanabe T. Molecular evolution of enzymes involved in the arachidonic acid cascade. Mediators Inflamm. 1992;1(4):223-33doi: 10.1155/S0962935192000346.
Toh, H., Urade, Y., & Tanabe, T. (1992). Molecular evolution of enzymes involved in the arachidonic acid cascade. Mediators of inflammation, 1(4), 223-33. https://doi.org/10.1155/S0962935192000346
Toh, H, et al. "Molecular evolution of enzymes involved in the arachidonic acid cascade." Mediators of inflammation vol. 1,4 (1992): 223-33. doi: https://doi.org/10.1155/S0962935192000346
Toh H, Urade Y, Tanabe T. Molecular evolution of enzymes involved in the arachidonic acid cascade. Mediators Inflamm. 1992;1(4):223-33. doi: 10.1155/S0962935192000346. PMID: 18475465; PMCID: PMC2365353.
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Mediators Inflamm. 1992;1(4):223-33. doi: 10.1155/S0962935192000346.

Molecular evolution of enzymes involved in the arachidonic acid cascade.

Mediators of inflammation

H Toh, Y Urade, T Tanabe

Affiliations

  1. Protein Engineering Research Institute 6-2-3 Furuedai Suita 565 Japan.

PMID: 18475465 PMCID: PMC2365353 DOI: 10.1155/S0962935192000346

Abstract

The metabolic pathway called the arachidonic acid cascade produces a wide range of eicosanoids, such as prostaglandins, thromboxanes and leukotrienes with potent biological activities. Recombinant DNA techniques have made it possible to determine the nucleotide sequences of cDNAs and/or genomic structures for the enzymes involved in the pathway. Sequence comparison analyses of the accumulated sequence data have brought great insights into the structure, function and molecular evolution of the enzymes. This paper reviews the sequence comparison analyses of the enzymes involved in the arachidonic acid cascade.

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