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Dobbins DE. Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb. Mediators Inflamm. 1992;1(6):391-5doi: 10.1155/S0962935192000590.
Dobbins, D. E. (1992). Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb. Mediators of inflammation, 1(6), 391-5. https://doi.org/10.1155/S0962935192000590
Dobbins, D E. "Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb." Mediators of inflammation vol. 1,6 (1992): 391-5. doi: https://doi.org/10.1155/S0962935192000590
Dobbins DE. Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb. Mediators Inflamm. 1992;1(6):391-5. doi: 10.1155/S0962935192000590. PMID: 18475490; PMCID: PMC2365367.
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Mediators Inflamm. 1992;1(6):391-5. doi: 10.1155/S0962935192000590.

Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb.

Mediators of inflammation

D E Dobbins

Affiliations

  1. Department of Physiology Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda MD 20814-4799 USA.

PMID: 18475490 PMCID: PMC2365367 DOI: 10.1155/S0962935192000590

Abstract

Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 x 10(-6), 7.47 x 10(-5) and 7.47 x 10(-4) M) increased lymphatic perfusion pressure at the two highest infusion rates. PAF mediated lymphatic constriction was not altered by the intra-arterial infusion of phentolamine but was blocked by the intra-arterial infusion of the PAF receptor antagonist WEB 2170. These data indicate that in addition to PAF's effects on microvascular permeability, this agent may also impact the ability of the lymphatics to transport fluid through alterations in lymphatic smooth muscle tone. PAF mediated lymphatic constriction is not mediated by alpha-receptors but rather through PAF receptor mediated mechanism.

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