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Clement MG, Dimori M, Albertini M. Comparison of vascular and respiratory effects of endothelin-1 in the pig. Mediators Inflamm. 1993;2(4):287-92doi: 10.1155/S0962935193000390.
Clement, M. G., Dimori, M., & Albertini, M. (1993). Comparison of vascular and respiratory effects of endothelin-1 in the pig. Mediators of inflammation, 2(4), 287-92. https://doi.org/10.1155/S0962935193000390
Clement, M G, et al. "Comparison of vascular and respiratory effects of endothelin-1 in the pig." Mediators of inflammation vol. 2,4 (1993): 287-92. doi: https://doi.org/10.1155/S0962935193000390
Clement MG, Dimori M, Albertini M. Comparison of vascular and respiratory effects of endothelin-1 in the pig. Mediators Inflamm. 1993;2(4):287-92. doi: 10.1155/S0962935193000390. PMID: 18475535; PMCID: PMC2365418.
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Mediators Inflamm. 1993;2(4):287-92. doi: 10.1155/S0962935193000390.

Comparison of vascular and respiratory effects of endothelin-1 in the pig.

Mediators of inflammation

M G Clement, M Dimori, M Albertini

Affiliations

  1. Institute of Veterinary Physiology and Biochemistry University of Milan Via Celoria 10 Milan 20133 Italy.

PMID: 18475535 PMCID: PMC2365418 DOI: 10.1155/S0962935193000390

Abstract

The haemodynamic and respiratory responses caused by i.v. administration of endothelin-1 (ET-1) (20-100 pmol/kg) were studied in anaesthetized spontaneously breathing pigs. Intravenous bolus administration of synthetic ET-1 (40-100 pmol/kg) caused a transient decrease followed by a long-lasting increase in mean pulmonary arterial pressure and dose dependent vasoconstriction both in the systemic and pulmonary circulations. The effect on pulmonary arterial pressure was biphasic, with an initial transient fall followed by a long-lasting dose dependent increase. A biphasic response of the systemic mean arterial pressure was demonstrated only at a high dose of ET-1 (100 pmol/kg). ET-1 administration did not significantly change breathing pattern or phasic vagal input, but caused a significant decrease in passive compliance. Passive resistances or active compliance and resistances of the respiratory system were not modified. These results suggest that in the pig ET-1 is a more potent constrictor of vascular than of bronchial smooth muscle. The vasoconstrictor activity was greater in the pulmonary than the systemic circulations.

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