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Kiehl R, Ionescu G. Pathological changes in platelet histamine oxidases in atopic eczema. Mediators Inflamm. 1993;2(6):403-6doi: 10.1155/S0962935193000560.
Kiehl, R., & Ionescu, G. (1993). Pathological changes in platelet histamine oxidases in atopic eczema. Mediators of inflammation, 2(6), 403-6. https://doi.org/10.1155/S0962935193000560
Kiehl, R, and Ionescu, G. "Pathological changes in platelet histamine oxidases in atopic eczema." Mediators of inflammation vol. 2,6 (1993): 403-6. doi: https://doi.org/10.1155/S0962935193000560
Kiehl R, Ionescu G. Pathological changes in platelet histamine oxidases in atopic eczema. Mediators Inflamm. 1993;2(6):403-6. doi: 10.1155/S0962935193000560. PMID: 18475554; PMCID: PMC2365432.
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Mediators Inflamm. 1993;2(6):403-6. doi: 10.1155/S0962935193000560.

Pathological changes in platelet histamine oxidases in atopic eczema.

Mediators of inflammation

R Kiehl, G Ionescu

Affiliations

  1. Research Department Spezialklinik Neukirchen Neukirchen 93453 Germany.

PMID: 18475554 PMCID: PMC2365432 DOI: 10.1155/S0962935193000560

Abstract

Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients. The diamine oxidase has almost normal cofactor levels (pyridoxal phosphate and Cu(2+)) but the cofactor levels for type B monoamine oxidase (flavin adenine dinucleotide and Fe(2+)) are lowered. The biogenic amines putrescine, cadaverine, spermidine, spermine, tyramine and serotonin in the sera, as well as dopamine and epinephrine in EDTA-plasma were found to be normal. It is unlikely, therefore, that these amines are responsible for the decreased activities of monoamine and diamine oxidase in these patients. The most likely causative factors for the inhibition of the diamine oxidase are nicotine, alcohol, food additives and other environmental chemicals, or perhaps a genetic defect of the diamine oxidase.

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