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Gold D, Nissimov L, Lengy J, et al. Anti- schistosomular activity of human monocytes/macrophages in response to interleukin-3 and granulocyte-macrophage colonystimulating factor stimulation. Mediators Inflamm. 1994;3(5):329-33doi: 10.1155/S0962935194000451.
Gold, D., Nissimov, L., Lengy, J., & Keisari, Y. (1994). Anti- schistosomular activity of human monocytes/macrophages in response to interleukin-3 and granulocyte-macrophage colonystimulating factor stimulation. Mediators of inflammation, 3(5), 329-33. https://doi.org/10.1155/S0962935194000451
Gold, D, et al. "Anti- schistosomular activity of human monocytes/macrophages in response to interleukin-3 and granulocyte-macrophage colonystimulating factor stimulation." Mediators of inflammation vol. 3,5 (1994): 329-33. doi: https://doi.org/10.1155/S0962935194000451
Gold D, Nissimov L, Lengy J, Keisari Y. Anti- schistosomular activity of human monocytes/macrophages in response to interleukin-3 and granulocyte-macrophage colonystimulating factor stimulation. Mediators Inflamm. 1994;3(5):329-33. doi: 10.1155/S0962935194000451. PMID: 18475576; PMCID: PMC2365577.
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Mediators Inflamm. 1994;3(5):329-33. doi: 10.1155/S0962935194000451.

Anti- schistosomular activity of human monocytes/macrophages in response to interleukin-3 and granulocyte-macrophage colonystimulating factor stimulation.

Mediators of inflammation

D Gold, L Nissimov, J Lengy, Y Keisari

Affiliations

  1. Department of Human Microbiology Sackler Faculty of Medicine Tel Aviv University Tel Aviv 69978 Israel.

PMID: 18475576 PMCID: PMC2365577 DOI: 10.1155/S0962935194000451

Abstract

Human monocytes, co-incubated for 7 days in culture with GM-CSF or IL-3 but not with IFN-gamma, exerted a variable schistosotnulicidal effect on Schistosoma mansoni parasites when grown in 96-well round-bottomed plates but not in flat-bottomed plates. Addition of LPS or IFN-gamma or both, for the last 48 h did not enhance the cidal effect. Addition of LPS but not IFN-gamma to the pre-incubated cells with GM-CSF or IL-3 markedly stimulated TNF-alpha production by the cells but not their cidal activity. The variable cidal effects obtained with the monocytes/macrophages from different donors suggest that these effects may be genetically predetermined and are possibly linked to blood group markers or to MHC class I or II antigens.

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