Display options
Cite
Moodley I, Sotsios Y, Bertin B. Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators Inflamm. 1995;4(2):112-6doi: 10.1155/S0962935195000196.
Moodley, I., Sotsios, Y., & Bertin, B. (1995). Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators of inflammation, 4(2), 112-6. https://doi.org/10.1155/S0962935195000196
Moodley, I, et al. "Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors." Mediators of inflammation vol. 4,2 (1995): 112-6. doi: https://doi.org/10.1155/S0962935195000196
Moodley I, Sotsios Y, Bertin B. Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators Inflamm. 1995;4(2):112-6. doi: 10.1155/S0962935195000196. PMID: 18475626; PMCID: PMC2365615.
Copy Download .nbib Format: NLM
Share it on

Mediators Inflamm. 1995;4(2):112-6. doi: 10.1155/S0962935195000196.

Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors.

Mediators of inflammation

I Moodley, Y Sotsios, B Bertin

Affiliations

  1. Institut de Recherche Jouveinal 9 rue de la Loge Fresnes Cedex 94265 France.

PMID: 18475626 PMCID: PMC2365615 DOI: 10.1155/S0962935195000196

Abstract

The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED(30) values at 24 h before challenge for rolipram, Ro 20-1724 and theophylline were 2.1, 5.4 and 30.4 mg/kg, p.o., respectively. Milrinone and SKF 94836 at 30 mg/kg caused a small, but significant inhibition of 13% and 18%, respectively, although the inhibition (8%) caused by zaprinast was not significant. Betamethasone (10 mg/kg, p.o.) caused a marked inhibition (80%) as did indomethacin (65% at 5 mg/kg, p.o.). Rolipram and Ro 20-1724 inhibited proliferation of mouse lymphoblasts with IC(50) values of 0.08 muM and 0.83 muM, respectively. In contrast, zaprinast caused only a weak inhibition (IC(50) = 119 muM) of lymphocyte proliferation, whereas SKF 94836 and theophylline failed to cause any significant inhibition at 100 muM (26% and 2%, respectively). These findings suggest that PDE IV isozymes play a principal role in mediating CS by inhibiting lymphocyte activation.

References

  1. Pharmacol Ther. 1991;51(1):13-33 - PubMed
  2. Biochem Biophys Res Commun. 1990 Jun 29;169(3):864-72 - PubMed
  3. Br J Pharmacol. 1981 Aug;73(4):933-8 - PubMed
  4. J Exp Med. 1990 Jul 1;172(1):95-103 - PubMed
  5. J Immunol. 1990 Jun 1;144(11):4121-8 - PubMed
  6. Eur J Pharmacol. 1994 Apr 1;255(1-3):253-6 - PubMed
  7. Annu Rev Immunol. 1989;7:145-73 - PubMed
  8. Immunol Today. 1991 Nov;12(11):392-5 - PubMed
  9. J Immunol. 1987 Jun 1;138(11):3688-94 - PubMed
  10. J Immunol. 1994 Apr 1;152(7):3391-9 - PubMed
  11. J Immunol. 1991 Apr 1;146(7):2285-96 - PubMed
  12. Biochem Pharmacol. 1991 Jul 25;42(4):869-77 - PubMed
  13. Mol Pharmacol. 1993 Nov;44(5):1027-35 - PubMed
  14. J Invest Dermatol. 1985 Jun;84(6):477-82 - PubMed
  15. J Invest Dermatol. 1992 Jul;99(1):65-70 - PubMed
  16. Lancet. 1994 May 28;343(8909):1338-41 - PubMed

Publication Types