Display options
Cite
Howard-Lock HE. Structures of gold(i) and silver(i) thiolate complexes of medicinal interest: a review and recent results. Met Based Drugs. 1999;6(4):201-9doi: 10.1155/MBD.1999.201.
Howard-Lock, H. E. (1999). Structures of gold(i) and silver(i) thiolate complexes of medicinal interest: a review and recent results. Metal-based drugs, 6(4), 201-9. https://doi.org/10.1155/MBD.1999.201
Howard-Lock, H E. "Structures of gold(i) and silver(i) thiolate complexes of medicinal interest: a review and recent results." Metal-based drugs vol. 6,4 (1999): 201-9. doi: https://doi.org/10.1155/MBD.1999.201
Howard-Lock HE. Structures of gold(i) and silver(i) thiolate complexes of medicinal interest: a review and recent results. Met Based Drugs. 1999;6(4):201-9. doi: 10.1155/MBD.1999.201. PMID: 18475894; PMCID: PMC2365178.
Copy Download .nbib Format: NLM
Share it on

Met Based Drugs. 1999;6(4):201-9. doi: 10.1155/MBD.1999.201.

Structures of gold(i) and silver(i) thiolate complexes of medicinal interest: a review and recent results.

Metal-based drugs

H E Howard-Lock

Affiliations

  1. Laboratories for Inorganic Medicine McMaster University Hamilton, ON L8S 4M1 Canada.

PMID: 18475894 PMCID: PMC2365178 DOI: 10.1155/MBD.1999.201

Abstract

We review the crystal structures, electrospray ionization mass spectra (ESI-MS) data and chiral HPLC data for the racemic and optically pure mononuclear AuL2 complexes, and for racemic [AuLI]n and optically pure [AgLII]n polymers (LI = thiomalate, LII = D-penicillamine). We postulate an equilibrium between polymeric, mononuclear and free ligand species for [AuLII]n (gold sodium thiomalate or GST). The ESI-MS results clearly show a tetrameric principal species in the 1:1 gold polymers, [AuLI]n. For the 1:1 silver: D-penicillamine complex, [AgLII]n, a non-molecular crystal of double helical structure, the ESI-MS results show multi-ligand-silver species, including tetramers, pentamers and hexamers. Other, relevant gold, silver and copper complexes are compared.

Publication Types