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McGregor JA, French JI. Pathogenesis to treatment: preventing preterm birth mediated by infection. Infect Dis Obstet Gynecol. 1997;5(2):106-14doi: 10.1155/S1064744997000173.
McGregor, J. A., & French, J. I. (1997). Pathogenesis to treatment: preventing preterm birth mediated by infection. Infectious diseases in obstetrics and gynecology, 5(2), 106-14. https://doi.org/10.1155/S1064744997000173
McGregor, J A, and French, J I. "Pathogenesis to treatment: preventing preterm birth mediated by infection." Infectious diseases in obstetrics and gynecology vol. 5,2 (1997): 106-14. doi: https://doi.org/10.1155/S1064744997000173
McGregor JA, French JI. Pathogenesis to treatment: preventing preterm birth mediated by infection. Infect Dis Obstet Gynecol. 1997;5(2):106-14. doi: 10.1155/S1064744997000173. PMID: 18476162; PMCID: PMC2364559.
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Infect Dis Obstet Gynecol. 1997;5(2):106-14. doi: 10.1155/S1064744997000173.

Pathogenesis to treatment: preventing preterm birth mediated by infection.

Infectious diseases in obstetrics and gynecology

J A McGregor, J I French

Affiliations

  1. Department of Obstetrics and Gynecology University of Colorado Health Sciences Center 4200 East Ninth Avenue Campus Box B198 Denver CO 80262 USA.

PMID: 18476162 PMCID: PMC2364559 DOI: 10.1155/S1064744997000173

Abstract

Prevention of preterm birth and subsequent newborn immaturity is a primary goal of obstetrical care worldwide. Accumulated evidence shows that 1) as many as 25-50% of preterm births are caused by common genital tract infections and subsequent maternal/fetal inflammatory responses; 2) microbial and maternal host factors (phospholipases, proteases, etc.) play roles in preterm labor and preterm premature rupture of membranes (pPROM); 3) integrated aspects of maternal and fetal host responses (inflammation, altered immune adaptations, endocrine and paracrine mechanisms) play increasingly understood roles in premature activation of parturition; and 4) identification and systemic treatment of common genitourinary infections, most importantly bacterial vaginosis (BV), reduce the risks of preterm delivery and PROM.

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