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Blétry O, Piette AM. Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects. Infect Dis Obstet Gynecol. 1997;5(2):183-91doi: 10.1155/S1064744997000288.
Blétry, O., & Piette, A. M. (1997). Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects. Infectious diseases in obstetrics and gynecology, 5(2), 183-91. https://doi.org/10.1155/S1064744997000288
Blétry, O, and Piette, A M. "Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects." Infectious diseases in obstetrics and gynecology vol. 5,2 (1997): 183-91. doi: https://doi.org/10.1155/S1064744997000288
Blétry O, Piette AM. Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects. Infect Dis Obstet Gynecol. 1997;5(2):183-91. doi: 10.1155/S1064744997000288. PMID: 18476173; PMCID: PMC2364563.
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Infect Dis Obstet Gynecol. 1997;5(2):183-91. doi: 10.1155/S1064744997000288.

Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects.

Infectious diseases in obstetrics and gynecology

O Blétry, A M Piette

Affiliations

  1. Service de Médecine Interne Hôpital Foch 40 rue Worth Suresnes 92151 France.

PMID: 18476173 PMCID: PMC2364563 DOI: 10.1155/S1064744997000288

Abstract

Recurrent fetal losses indicate screening for antiphospholipid antibodies, especially after the third consecutive fetal loss, or when they occur after 12 weeks gestation or when the mother presents with thrombosis or other ailments of antiphospholipid syndrome. Fetal loss may be caused by thromboses of placental vasculature. There is no agreement concerning the mechanism of thromboses: protein C pathway and/or annexin V are the best candidates. When fetal loss occurs early during gestation, murine models suggest that antiphospholipid antibodies can also act on trophoblasts by inhibiting syncytia formation. Among the high risk patients with more than two fetal losses, an association of aspirin and heparin given early during gestation is successful in 70-80% of cases.

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