Display options
Cite
Tiekink ER, Cookson PD, Linahan BM, et al. In vitro antitumour activity of some triorganophosphinegold(i) thionucleobases. Met Based Drugs. 1994;1(4):299-304doi: 10.1155/MBD.1994.299.
Tiekink, E. R., Cookson, P. D., Linahan, B. M., & Webster, L. K. (1994). In vitro antitumour activity of some triorganophosphinegold(i) thionucleobases. Metal-based drugs, 1(4), 299-304. https://doi.org/10.1155/MBD.1994.299
Tiekink, E R, et al. "In vitro antitumour activity of some triorganophosphinegold(i) thionucleobases." Metal-based drugs vol. 1,4 (1994): 299-304. doi: https://doi.org/10.1155/MBD.1994.299
Tiekink ER, Cookson PD, Linahan BM, Webster LK. In vitro antitumour activity of some triorganophosphinegold(i) thionucleobases. Met Based Drugs. 1994;1(4):299-304. doi: 10.1155/MBD.1994.299. PMID: 18476243; PMCID: PMC2364903.
Copy Download .nbib Format: NLM
Share it on

Met Based Drugs. 1994;1(4):299-304. doi: 10.1155/MBD.1994.299.

In vitro antitumour activity of some triorganophosphinegold(i) thionucleobases.

Metal-based drugs

E R Tiekink, P D Cookson, B M Linahan, L K Webster

Affiliations

  1. Department of Chemistry The University of Adelaide Adelaide South Australia 5005 Australia.

PMID: 18476243 PMCID: PMC2364903 DOI: 10.1155/MBD.1994.299

Abstract

A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID(50) values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 muM. The complexes with SR(3) and SR(3) are generally the most active; however, there is no clear trend associated with the phosphine ligands.

Publication Types