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Gielen M, El Khloufi A, Biesemans M, et al. Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates. Met Based Drugs. 1994;1(4):305-9doi: 10.1155/MBD.1994.305.
Gielen, M., El Khloufi, A., Biesemans, M., Bouhdid, A., de Vos, D., Mahieu, B., & Willem, R. (1994). Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates. Metal-based drugs, 1(4), 305-9. https://doi.org/10.1155/MBD.1994.305
Gielen, M, et al. "Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates." Metal-based drugs vol. 1,4 (1994): 305-9. doi: https://doi.org/10.1155/MBD.1994.305
Gielen M, El Khloufi A, Biesemans M, Bouhdid A, de Vos D, Mahieu B, Willem R. Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates. Met Based Drugs. 1994;1(4):305-9. doi: 10.1155/MBD.1994.305. PMID: 18476244; PMCID: PMC2364906.
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Met Based Drugs. 1994;1(4):305-9. doi: 10.1155/MBD.1994.305.

Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates.

Metal-based drugs

M Gielen, A El Khloufi, M Biesemans, A Bouhdid, D de Vos, B Mahieu, R Willem

Affiliations

  1. Free University of Brussels (V.U.B.) Pleinlaan 2 Faculty of Applied Sciences Laboratory for General and Organic Chemistry (AOSC), Room 8G512 Brussels B-1050 Belgium.

PMID: 18476244 PMCID: PMC2364906 DOI: 10.1155/MBD.1994.305

Abstract

The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.

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