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Vargas E, Simón J, Martin JC, et al. Effect of adverse drug reactions on length of stay in intensive care units. Clin Drug Investig. 1998;15(4):353-60doi: 10.2165/00044011-199815040-00011.
Vargas, E., Simón, J., Martin, J. C., Puerro, M., Gonzalez-Callejo, M. A., Jaime, M., Gomez-Mayoral, B., Duque, F., Gomez-Delgado, A., & Moreno, A. (1998). Effect of adverse drug reactions on length of stay in intensive care units. Clinical drug investigation, 15(4), 353-60. https://doi.org/10.2165/00044011-199815040-00011
Vargas, E, et al. "Effect of adverse drug reactions on length of stay in intensive care units." Clinical drug investigation vol. 15,4 (1998): 353-60. doi: https://doi.org/10.2165/00044011-199815040-00011
Vargas E, Simón J, Martin JC, Puerro M, Gonzalez-Callejo MA, Jaime M, Gomez-Mayoral B, Duque F, Gomez-Delgado A, Moreno A. Effect of adverse drug reactions on length of stay in intensive care units. Clin Drug Investig. 1998;15(4):353-60. doi: 10.2165/00044011-199815040-00011. PMID: 18370490.
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Clin Drug Investig. 1998;15(4):353-60. doi: 10.2165/00044011-199815040-00011.

Effect of adverse drug reactions on length of stay in intensive care units.

Clinical drug investigation

E Vargas, J Simón, J C Martin, M Puerro, M A Gonzalez-Callejo, M Jaime, B Gomez-Mayoral, F Duque, A Gomez-Delgado, A Moreno

Affiliations

  1. Clinical Pharmacology Service, Hospital Clínico San Carlos, Madrid, Spain.

PMID: 18370490 DOI: 10.2165/00044011-199815040-00011

Abstract

The objective of the present study was to determine the frequency of adverse drug reactions (ADRs) in intensive care units (ICUs) and to evaluate their effect on the length of stay. We performed a prospective study to detect ADRs in 420 patients hospitalised in 10 predetermined beds in the ICU of our hospital between the months of March and December 1996. While the patients were staying in the ICU, data was gathered regarding suspected ADRs and on different variables related to the length of stay. 96 different ADRs were detected in 85 of the 420 patients seen [20.2%, 95% confidence intervals (95% CI) 16.5 to 24.4]. The ADRs were most frequently caused by the following drugs: nitrates (n = 25), opiates (n = 21) and ultrashort-acting benzodiazepines (n = 10). Eight ADRs were severe, the suspected medication had to be discontinued in 51 cases and new drugs were necessary to manage the ADRs in 73 cases. The crude estimation of the effect of the number of ADRs performed with a bivariant regression model indicated that each ADR was related to a 2.38-day increase (95% CI 1.31 to 3.45) in the length of stay. Although this estimation was reduced to 1.76 days (95% CI 0.72 to 2.79), when other confounding variables associated with the length of stay were considered, it was still important.In conclusion, the ADRs were a significant clinical problem in the ICUs and were responsible for a significant increase in the length of stay.

References

  1. J Intern Med. 1990 Oct;228(4):379-84 - PubMed
  2. Crit Care Med. 1985 Oct;13(10):818-29 - PubMed
  3. Postgrad Med J. 1979 Dec;55(654):870-3 - PubMed
  4. Rev Clin Esp. 1992 Oct;191(5):270-3 - PubMed
  5. Am J Surg. 1976 Nov;132(5):643-5 - PubMed
  6. Br Med J. 1979 Nov 10;2(6199):1194-7 - PubMed
  7. QRB Qual Rev Bull. 1993 May;19(5):144-9 - PubMed
  8. Arch Intern Med. 1976 Aug;136(8):872-5 - PubMed
  9. JAMA. 1997 Jan 22-29;277(4):307-11 - PubMed
  10. Br Med J. 1973 May 19;2(5863):407-10 - PubMed
  11. Eur J Clin Pharmacol. 1977 Mar 11;11(3):181-92 - PubMed
  12. Med Clin (Barc). 1997 May 3;108(17):647-51 - PubMed
  13. Eur J Clin Pharmacol. 1987;31(5):507-12 - PubMed
  14. Am J Health Syst Pharm. 1995 Nov 1;52(21):2415-8 - PubMed
  15. Med Clin (Barc). 1989 Apr 15;92(14):530-5 - PubMed
  16. Int J Clin Pharmacol Biopharm. 1976 Apr;13(3):187-95 - PubMed
  17. JAMA. 1997 Jan 22-29;277(4):301-6 - PubMed
  18. Clin Pharmacol Ther. 1981 Aug;30(2):239-45 - PubMed
  19. Am J Hosp Pharm. 1978 Sep;35(9):1060-4 - PubMed
  20. Br J Clin Pharmacol. 1992 Jan;33(1):61-8 - PubMed
  21. JAMA. 1995 Jul 5;274(1):29-34 - PubMed
  22. Med Clin (Barc). 1984 Mar 17;82(10):433-7 - PubMed
  23. JAMA. 1974 May 6;228(6):713-7 - PubMed
  24. Arch Intern Med. 1986 Oct;146(10):1931-4 - PubMed
  25. JAMA. 1977 Feb 28;237(9):879-81 - PubMed
  26. JAMA. 1975 Dec 22;234(12):1236-41 - PubMed
  27. Respiration. 1992;59(1):30-4 - PubMed
  28. JAMA. 1976 Aug 9;236(6):575-8 - PubMed
  29. Arch Intern Med. 1995 Oct 9;155(18):1949-56 - PubMed
  30. Proc Annu Symp Comput Appl Med Care. 1993;:161-5 - PubMed
  31. J Chronic Dis. 1986;39(7):533-42 - PubMed
  32. JAMA. 1982 Sep 24;248(12):1482-5 - PubMed
  33. Ann Intern Med. 1993 May 15;118(10):753-61 - PubMed
  34. S Afr Med J. 1985 May 11;67(19):770-2 - PubMed
  35. Acta Med Scand. 1979;205(6):451-6 - PubMed
  36. BMJ. 1995 Oct 14;311(7011):1003-6 - PubMed
  37. Med Clin (Barc). 1986 Jun 21;87(4):131-4 - PubMed
  38. Br Med J. 1969 Mar 1;1(5643):536-9 - PubMed
  39. Med Clin (Barc). 1994 Jun 11;103(2):49-53 - PubMed
  40. Rev Med Interne. 1987 Mar-Apr;8(2):173-9 - PubMed
  41. Ann Pharmacother. 1993 Jul-Aug;27(7-8):832-40 - PubMed
  42. JAMA. 1971 Apr 19;216(3):467-72 - PubMed
  43. Br Med J. 1974 Mar 16;1(5906):501-4 - PubMed

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