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Cresci S. PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. PPAR Res. 2008;2008:374549doi: 10.1155/2008/374549.
Cresci, S. (2008). PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. PPAR research, 2008374549. https://doi.org/10.1155/2008/374549
Cresci, Sharon. "PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease." PPAR research vol. 2008 (2008): 374549. doi: https://doi.org/10.1155/2008/374549
Cresci S. PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. PPAR Res. 2008;2008:374549. doi: 10.1155/2008/374549. PMID: 18401448; PMCID: PMC2288645.
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PPAR Res. 2008;2008:374549. doi: 10.1155/2008/374549.

PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease.

PPAR research

Sharon Cresci

Affiliations

  1. Department of Medicine, Washington University School of Medicine, Washington University, Saint Louis, MO 63110, USA.

PMID: 18401448 PMCID: PMC2288645 DOI: 10.1155/2008/374549

Abstract

The peroxisome proliferator-activated receptors (PPARs) consist of three related transcription factors that serve to regulate a number of cellular processes that are central to cardiovascular health and disease. Numerous pharmacologic studies have assessed the effects of specific PPAR agonists in clinical trials and have provided insight into the clinical effects of these genes while genetic studies have demonstrated clinical associations between PPAR polymorphisms and abnormal cardiovascular phenotypes. With the abundance of data available from these studies as a background, PPAR pharmacogenetics has become a promising and rapidly advancing field. This review focuses on summarizing the current state of understanding of PPAR genetics and pharmacogenetics and the important implications for the individualization of therapy for patients with cardiovascular diseases.

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