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Guiducci S, Cerinic MM. Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis. Nat Clin Pract Rheumatol. 2008;4(6):288-9doi: 10.1038/ncprheum0803.
Guiducci, S., & Cerinic, M. M. (2008). Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis. Nature clinical practice. Rheumatology, 4(6), 288-9. https://doi.org/10.1038/ncprheum0803
Guiducci, Serena, and Cerinic, Marco Matucci. "Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis." Nature clinical practice. Rheumatology vol. 4,6 (2008): 288-9. doi: https://doi.org/10.1038/ncprheum0803
Guiducci S, Cerinic MM. Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):288-9. doi: 10.1038/ncprheum0803. Epub 2008 May 06. PMID: 18461063.
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Nat Clin Pract Rheumatol. 2008 Jun;4(6):288-9. doi: 10.1038/ncprheum0803. Epub 2008 May 06.

Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis.

Nature clinical practice. Rheumatology

Serena Guiducci, Marco Matucci Cerinic

Affiliations

  1. Department of BioMedicine, Division of Rheumatology at the University of Florence, Italy. [email protected]

PMID: 18461063 DOI: 10.1038/ncprheum0803

Abstract

Gliddon et al. conducted a randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy of the angiotensin-converting enzyme inhibitor quinapril for the management of vascular damage in systemic sclerosis (SSc). The trial comprised 213 patients with limited cutaneous SSc or Raynaud's phenomenon (mean age 54 years, 182 females) who were randomly assigned to receive 80 mg/day, or the maximum tolerated dose, of quinapril (n = 105) or placebo (n = 108) for 2-3 years. Patients were assessed every 3 months. The number of new ischemic digital ulcers was recorded as the primary end point, while the frequency of Raynaud's phenomenon episodes, skin score, health status, pulmonary artery pressure and treatments for ischemia were also monitored as secondary end points. There were no detectable differences between patients treated with quinapril and those receiving placebo; however, although no severe adverse effects were observed, patients taking quinapril experienced significantly more adverse effects.

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