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Whitworth DJ. XX germ cells: the difference between an ovary and a testis. Trends Endocrinol Metab. 1998;9(1):2-6doi: 10.1016/s1043-2760(98)00002-2.
Whitworth, D. J. (1998). XX germ cells: the difference between an ovary and a testis. Trends in endocrinology and metabolism: TEM, 9(1), 2-6. https://doi.org/10.1016/s1043-2760(98)00002-2
Whitworth, D J. "XX germ cells: the difference between an ovary and a testis." Trends in endocrinology and metabolism: TEM vol. 9,1 (1998): 2-6. doi: https://doi.org/10.1016/s1043-2760(98)00002-2
Whitworth DJ. XX germ cells: the difference between an ovary and a testis. Trends Endocrinol Metab. 1998 Jan-Feb;9(1):2-6. doi: 10.1016/s1043-2760(98)00002-2. PMID: 18406227.
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Trends Endocrinol Metab. 1998 Jan-Feb;9(1):2-6. doi: 10.1016/s1043-2760(98)00002-2.

XX germ cells: the difference between an ovary and a testis.

Trends in endocrinology and metabolism: TEM

D J Whitworth

Affiliations

  1. Department of Molecular Genetics, Box 45, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 18406227 DOI: 10.1016/s1043-2760(98)00002-2

Abstract

In mammals, gonadal sex is determined by the action of the testis-determining gene, SRY. In the absence of SRY, the indifferent gonad follows an alternative pathway and develops as an ovary. Both mitotic and meiotic germ cells appear to play an essential role in ensuring ovarian development. Ovaries depleted of germ cells before or after ovarian differentiation has commenced can develop seminiferous cords, suggesting that XX germ cells may inhibit testicular differentiation in the ovary.

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