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Lim CF, Stockigt JR, Hennemann G. Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation. Trends Endocrinol Metab. 1995;6(1):17-20doi: 10.1016/1043-2760(94)00095-l.
Lim, C. F., Stockigt, J. R., & Hennemann, G. (1995). Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation. Trends in endocrinology and metabolism: TEM, 6(1), 17-20. https://doi.org/10.1016/1043-2760(94)00095-l
Lim, C F, et al. "Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation." Trends in endocrinology and metabolism: TEM vol. 6,1 (1995): 17-20. doi: https://doi.org/10.1016/1043-2760(94)00095-l
Lim CF, Stockigt JR, Hennemann G. Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation. Trends Endocrinol Metab. 1995 Jan-Feb;6(1):17-20. doi: 10.1016/1043-2760(94)00095-l. PMID: 18406679.
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Trends Endocrinol Metab. 1995 Jan-Feb;6(1):17-20. doi: 10.1016/1043-2760(94)00095-l.

Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation.

Trends in endocrinology and metabolism: TEM

C F Lim, J R Stockigt, G Hennemann

Affiliations

  1. Ewen Downie Metabolic Unit, and Monash University Department of Medicine, Alfred Hospital, Melbourne, Victoria, Australia, 3181.

PMID: 18406679 DOI: 10.1016/1043-2760(94)00095-l

Abstract

Low plasma T(3) in severe illness is widely thought to be due principally to inhibition of 5'-deiodinase activity, but other factors also contribute to this response. Abnormal plasma constituents, namely, 3-carboxy-4-methyl-5-propyl-2-furan propanoic acid (CMPF) and indoxyl sulfate in uremia, and elevated bilirubin and nonesterified fatty acids (NEFA) can impair T(4) transport into hepatocytes, thereby contributing to the lowering of plasma T(3). Assessment of possible endogenous or exogenous inhibitors of T(4) binding to plasma proteins is prone to dilution-dependent artifacts, which can lead to overestimation or underestimation of competitor potency, depending on experimental details. Because the potency of such competitors is a function of their free concentrations in undiluted serum, inhibitory activity may be enhanced by substances that impair their albumin binding. Oleic acid or CMPF can inhibit the effect of drugs such as furosemide or fenclofenac.

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