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Hinkle PM, Nelson EJ, Ashworth R. Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells. Trends Endocrinol Metab. 1996;7(10):370-4doi: 10.1016/s1043-2760(96)00188-9.
Hinkle, P. M., Nelson, E. J., & Ashworth, R. (1996). Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells. Trends in endocrinology and metabolism: TEM, 7(10), 370-4. https://doi.org/10.1016/s1043-2760(96)00188-9
Hinkle, P M, et al. "Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells." Trends in endocrinology and metabolism: TEM vol. 7,10 (1996): 370-4. doi: https://doi.org/10.1016/s1043-2760(96)00188-9
Hinkle PM, Nelson EJ, Ashworth R. Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells. Trends Endocrinol Metab. 1996 Dec;7(10):370-4. doi: 10.1016/s1043-2760(96)00188-9. PMID: 18406774.
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Trends Endocrinol Metab. 1996 Dec;7(10):370-4. doi: 10.1016/s1043-2760(96)00188-9.

Characterization of the calcium response to thyrotropin-releasing hormone in lactotrophs and GH cells.

Trends in endocrinology and metabolism: TEM

P M Hinkle, E J Nelson, R Ashworth

Affiliations

  1. Patricia M. Hinkle, Eric J. Nelson, and Rachel Ashworth are at the Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

PMID: 18406774 DOI: 10.1016/s1043-2760(96)00188-9

Abstract

Thyrotropin-releasing hormone (TRH) acts via a G-protein-coupled receptor on lactotrophs to increase the intracellular free calcium ion concentration, [Ca(2+)](i). The [Ca(2+)](i) response depends on both TRH concentration and the duration of TRH exposure. An initial, short-lived [Ca(2+)](i) spike results from release of Ca(2+) from intracellular stores, whereas a later sustained [Ca(2+)](i) increase, often characterized by [Ca(2+)](i) oscillations, results from an influx of extracellular Ca(2+) through both voltage-gated and non-voltage-gated, store-operated Ca(2+) channels. The initial spike phase predominates at high doses of TRH, whereas the plateau phase predominates at low doses. The mechanisms underlying the complex [Ca(2+)](i) response to TRH are discussed.

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