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Nonogaki K, Iguchi A. Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines. Trends Endocrinol Metab. 1997;8(5):192-7doi: 10.1016/s1043-2760(97)00038-6.
Nonogaki, K., & Iguchi, A. (1997). Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines. Trends in endocrinology and metabolism: TEM, 8(5), 192-7. https://doi.org/10.1016/s1043-2760(97)00038-6
Nonogaki, K, and Iguchi, A. "Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines." Trends in endocrinology and metabolism: TEM vol. 8,5 (1997): 192-7. doi: https://doi.org/10.1016/s1043-2760(97)00038-6
Nonogaki K, Iguchi A. Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines. Trends Endocrinol Metab. 1997 Jul;8(5):192-7. doi: 10.1016/s1043-2760(97)00038-6. PMID: 18406806.
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Trends Endocrinol Metab. 1997 Jul;8(5):192-7. doi: 10.1016/s1043-2760(97)00038-6.

Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines.

Trends in endocrinology and metabolism: TEM

K Nonogaki, A Iguchi

Affiliations

  1. Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Geriatrics, Nagoya University School of Medicine, Nagoya, 466, Japan.

PMID: 18406806 DOI: 10.1016/s1043-2760(97)00038-6

Abstract

Stress is accompanied by metabolic alterations that could contribute to the etiology of diabetes mellitus, arteriosclerosis, and cardiovascular diseases; however, the mechanisms by which stress affects glucose and lipid metabolism remain to be resolved. Stress-induced effects on neurotransmission and interleukin-1 (IL-1) signaling rapidly produce hyperglycemia by increasing sympathetic outflow. Activation of the sympathetic nervous system can also rapidly stimulate lipolysis and hepatic triglyceride secretion. Furthermore, stress increases serum interleukin-6 (IL-6) and nerve growth factor (NGF) levels by activating neuroendocrine systems. IL-6 and NGF can rapidly increase lipolysis and hepatic triglyceride secretion without inducing hyperglycemia. The sympathetic nervous system does not mediate cytokine-induced hypertriglyceridemia. Thus, the central nervous system plays an important role in regulation of hepatic glucose and lipid metabolism via the sympathetic nervous system and cytokines. (Trends Endocrinol Metab 1997;8:192-197). (c) 1997, Elsevier Science Inc.

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