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Dumont JE, Maenhaut C, Lamy F. Control of thyroid cell proliferation and goitrogenesis. Trends Endocrinol Metab. 1992;3(1):12-7doi: 10.1016/1043-2760(92)90086-g.
Dumont, J. E., Maenhaut, C., & Lamy, F. (1992). Control of thyroid cell proliferation and goitrogenesis. Trends in endocrinology and metabolism: TEM, 3(1), 12-7. https://doi.org/10.1016/1043-2760(92)90086-g
Dumont, J E, et al. "Control of thyroid cell proliferation and goitrogenesis." Trends in endocrinology and metabolism: TEM vol. 3,1 (1992): 12-7. doi: https://doi.org/10.1016/1043-2760(92)90086-g
Dumont JE, Maenhaut C, Lamy F. Control of thyroid cell proliferation and goitrogenesis. Trends Endocrinol Metab. 1992 Jan-Feb;3(1):12-7. doi: 10.1016/1043-2760(92)90086-g. PMID: 18407072.
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Trends Endocrinol Metab. 1992 Jan-Feb;3(1):12-7. doi: 10.1016/1043-2760(92)90086-g.

Control of thyroid cell proliferation and goitrogenesis.

Trends in endocrinology and metabolism: TEM

J E Dumont, C Maenhaut, F Lamy

Affiliations

  1. Institute of Interdisciplinary Research, Faculty of Medicine, Erasmus Hospital, Free University of Brussels, Brussels, Belgium.

PMID: 18407072 DOI: 10.1016/1043-2760(92)90086-g

Abstract

Human thyroid cells proliferate during development and in adults in response to physiologic and pathologic stimuli. Under normal conditions, they turn over about once every 8 years. The main physiologic regulators are thyrotropin and iodide and, in disease, thyroid-stimulating and thyroid-blocking antibodies. Growth factors modulate proliferation in vitro, but their role in vivo is still unknown. Mitogenic effects are mediated via three major pathways: the cyclic AMP, protein tyrosine kinase, and the Ca(2+) phosphatidylinositol cascades. In this review, the role of these cascades in hyperthyroidism, congenital thyroid defects, and autonomous adenoma is analyzed.

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