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de Papp AE, Stewart AF. Parathyroid hormone-related protein a peptide of diverse physiologic functions. Trends Endocrinol Metab. 1993;4(6):181-7doi: 10.1016/1043-2760(93)90114-t.
de Papp, A. E., & Stewart, A. F. (1993). Parathyroid hormone-related protein a peptide of diverse physiologic functions. Trends in endocrinology and metabolism: TEM, 4(6), 181-7. https://doi.org/10.1016/1043-2760(93)90114-t
de Papp, A E, and Stewart, A F. "Parathyroid hormone-related protein a peptide of diverse physiologic functions." Trends in endocrinology and metabolism: TEM vol. 4,6 (1993): 181-7. doi: https://doi.org/10.1016/1043-2760(93)90114-t
de Papp AE, Stewart AF. Parathyroid hormone-related protein a peptide of diverse physiologic functions. Trends Endocrinol Metab. 1993 Aug;4(6):181-7. doi: 10.1016/1043-2760(93)90114-t. PMID: 18407154.
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Trends Endocrinol Metab. 1993 Aug;4(6):181-7. doi: 10.1016/1043-2760(93)90114-t.

Parathyroid hormone-related protein a peptide of diverse physiologic functions.

Trends in endocrinology and metabolism: TEM

A E de Papp, A F Stewart

Affiliations

  1. Anne E. de Papp and Andrew F. Stewart are at the Division of Endocrinology, West Haven Veterans Affairs Medical Center, West Haven, CT 06516, USA; Division of Endocrinology, Yale University School of Medicine, New Haven, CT 06510, USA.

PMID: 18407154 DOI: 10.1016/1043-2760(93)90114-t

Abstract

Parathyroid hormone-related protein (PTHrP) is the factor responsible for the syndrome of humoral hypercalcemia of malignancy. PTHrP is produced by a multitude o f normal as well as malignant cells, and exerts both classic parathyroid hormone (PTH)-like and PTH-unlike effects. The molecular cloning of the PTHrP gene, and the subsequent recognition of its widespread expression in normal tissues under normal physiologic conditions, has prompted intense inquiry into its biologic function. PTHrP appears to act in an autocrine or paracrine fashion in (a) normal embryogenesis and neonatal development, (b) cellular growth and differentiation, (c) reproduction and lactation, (d) epithelial calcium transport, and (e) smooth muscle relaxation. These five key emerging physiologic roles of PTHrP are the focus of this review.

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