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Ma H, Goryanin I. Human metabolic network reconstruction and its impact on drug discovery and development. Drug Discov Today. 2008;13(9):402-8doi: 10.1016/j.drudis.2008.02.002.
Ma, H., & Goryanin, I. (2008). Human metabolic network reconstruction and its impact on drug discovery and development. Drug discovery today, 13(9), 402-8. https://doi.org/10.1016/j.drudis.2008.02.002
Ma, Hongwu, and Goryanin, Igor. "Human metabolic network reconstruction and its impact on drug discovery and development." Drug discovery today vol. 13,9 (2008): 402-8. doi: https://doi.org/10.1016/j.drudis.2008.02.002
Ma H, Goryanin I. Human metabolic network reconstruction and its impact on drug discovery and development. Drug Discov Today. 2008 May;13(9):402-8. doi: 10.1016/j.drudis.2008.02.002. Epub 2008 Mar 24. PMID: 18468557.
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Drug Discov Today. 2008 May;13(9):402-8. doi: 10.1016/j.drudis.2008.02.002. Epub 2008 Mar 24.

Human metabolic network reconstruction and its impact on drug discovery and development.

Drug discovery today

Hongwu Ma, Igor Goryanin

Affiliations

  1. School of Informatics, the University of Edinburgh, Mayfield Road, Edinburgh, United Kingdom.

PMID: 18468557 DOI: 10.1016/j.drudis.2008.02.002

Abstract

This paper describes the process for the reconstruction of a high quality human metabolic network from the genome information, the existing problems in the reconstruction and why a time-consuming literature based consolidation process is needed. The reconstructed metabolic network provides a unified platform to integrate all the biological and medical information on genes, proteins, metabolites, disease, drugs and drug targets for a system level study of the relationship between metabolism and disease. System analysis of metabolic networks will help us, not only in identifying new drug targets but also in developing a system-oriented drug design strategy.

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