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Rusthoven JJ. Biological response modifiers and infectious diseases: actual and potential therapeutic agents. Int J Antimicrob Agents. 1994;3(4):223-43doi: 10.1016/0924-8579(94)90050-7.
Rusthoven, J. J. (1994). Biological response modifiers and infectious diseases: actual and potential therapeutic agents. International journal of antimicrobial agents, 3(4), 223-43. https://doi.org/10.1016/0924-8579(94)90050-7
Rusthoven, J J. "Biological response modifiers and infectious diseases: actual and potential therapeutic agents." International journal of antimicrobial agents vol. 3,4 (1994): 223-43. doi: https://doi.org/10.1016/0924-8579(94)90050-7
Rusthoven JJ. Biological response modifiers and infectious diseases: actual and potential therapeutic agents. Int J Antimicrob Agents. 1994;3(4):223-43. doi: 10.1016/0924-8579(94)90050-7. PMID: 18611565; PMCID: PMC7135342.
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Int J Antimicrob Agents. 1994;3(4):223-43. doi: 10.1016/0924-8579(94)90050-7.

Biological response modifiers and infectious diseases: actual and potential therapeutic agents.

International journal of antimicrobial agents

J J Rusthoven

Affiliations

  1. Hamilton Regional Cancer Centre, Ontario Cancer Foundation, Hamilton, Ont., Canada.

PMID: 18611565 PMCID: PMC7135342 DOI: 10.1016/0924-8579(94)90050-7

Abstract

Biological response modifiers (BRMs) are agents which can modify the immune response to cancer or invasion of the organism by infectious agents. An explosive appearance of new BRMs has resulted from the development of recombinant gene technology and the availability of monoclonal antibodies. Colony-stimulating factors first became available for the prevention of neutropenia but may also have a role in the treatment of infections. Interleukin-1 is being tested as a modular of hematopoiesis and may be useful as a helper factor for T- and B-cell function. Immunoglobulins are being used against viral and bacterial infections while interferons can prevent viral upper respiratory infections and suppress or irradicate some viral hepatitides. Other BRMs which show promise include chemical agents and traditional herbal medicines.

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