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Eliopoulos GM, Wennersten CB, Cole G, et al. In vitro activity of WY-49605, a penem antimicrobial. Int J Antimicrob Agents. 1995;5(4):251-7doi: 10.1016/0924-8579(95)00006-t.
Eliopoulos, G. M., Wennersten, C. B., Cole, G., & Moellering, R. C. (1995). In vitro activity of WY-49605, a penem antimicrobial. International journal of antimicrobial agents, 5(4), 251-7. https://doi.org/10.1016/0924-8579(95)00006-t
Eliopoulos, G M, et al. "In vitro activity of WY-49605, a penem antimicrobial." International journal of antimicrobial agents vol. 5,4 (1995): 251-7. doi: https://doi.org/10.1016/0924-8579(95)00006-t
Eliopoulos GM, Wennersten CB, Cole G, Moellering RC. In vitro activity of WY-49605, a penem antimicrobial. Int J Antimicrob Agents. 1995 Jul;5(4):251-7. doi: 10.1016/0924-8579(95)00006-t. PMID: 18611676.
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Int J Antimicrob Agents. 1995 Jul;5(4):251-7. doi: 10.1016/0924-8579(95)00006-t.

In vitro activity of WY-49605, a penem antimicrobial.

International journal of antimicrobial agents

G M Eliopoulos, C B Wennersten, G Cole, R C Moellering

Affiliations

  1. Department of Medicine, Deaconess Hospital One Deaconess Road, Boston, MA 02215, USA.

PMID: 18611676 DOI: 10.1016/0924-8579(95)00006-t

Abstract

The in vitro activity of the penem antimicrobial WY-49605 was compared with those of other agents available for oral administration. Based on concentrations inhibiting 90% of isolates (MIC(90)s), the penem inhibited methicillin-susceptible staphylococci (MIC(90) = 0.25 microg/ml), penicillin-susceptible streptococci (MIC(90) < or = 0.12 microg/ml) and several other Gram-positive genera at concentrations comparable or superior to the most active comparison agents. WY-49605 and cefpodoxime were the most active agents against members of the family Enterobacteriaceae. Most strains of Enterococcus faecalis and Bacteroides fragilis were susceptible to the new agent at concentrations < or =4microg/ml, while Pseudomonas aeruginosa, Enterococcus faecium, and methicillin-resistant Staphylococcus aureus were resistant to all agents tested.

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