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HSS J. 2006 Feb;2(1):62-9. doi: 10.1007/s11420-005-0137-8.

Osteoporosis and skeletal fractures.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Michael J Gardner, Demetris Demetrakopoulos, Michael K Shindle, Matthew H Griffith, Joseph M Lane

Affiliations

  1. Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. [email protected]

PMID: 18751849 PMCID: PMC2504115 DOI: 10.1007/s11420-005-0137-8

Abstract

Osteoporosis affects millions of individuals worldwide, rendering them susceptible to fragility fractures of the spine, hip, and wrist and leading to significant morbidity, mortality, and economic cost. Given the substantial impact of osteoporosis on both patients and the medical community, it is imperative that physicians improve awareness and knowledge of osteoporosis in the setting of low-energy fractures. In this review, we provide information on effective means of preventing fragility fractures and introduce clinicians to issues pertinent to the patient who suffers an osteoporotic fracture. Prevention of fragility fractures centers around adequate mineral nutrition, including daily calcium and vitamin D supplementation, as well as prescription antiresorptive medications such as bisphosphonates or teriparatide therapy in severe cases, both of which have been shown to decrease future fracture risk. Balance and strength training also play important roles in the management of the osteoporotic patient, particularly following a low-energy fracture, and external hip protectors may be useful for certain patients. Kyphoplasty and vertebroplasty are two minimally invasive techniques that show great promise in the treatment of vertebral compression fractures, although questions regarding long-term biomechanical effects still exist. Traditionally, osteoporosis has been underdiagnosed and undertreated following a low-energy fracture in an elderly patient. Although treatment rates may be improving through public health initiatives, the majority of patients with osteoporosis remain inadequately treated. Perioperative intervention programs that focus on patient education about osteoporosis and treatment options lead to significant increases in intervention and treatment. Reducing the risk of skeletal fractures in patients susceptible to osteoporosis involves improved physician education on the risk factors and management of osteoporosis, as well as informing patients on the significance of dual-energy X-ray absorptiometry testing and medical treatment so that they may serve as their own healthcare advocates in this often-undertreated disease.

References

  1. N Engl J Med. 1995 Nov 30;333(22):1437-43 - PubMed
  2. BMJ. 1995 Jul 22;311(6999):237-42 - PubMed
  3. J Orthop Sci. 2001;6(2):128-32 - PubMed
  4. Crit Rev Oncol Hematol. 2002 Jul;43(1):63-76 - PubMed
  5. Ann Rheum Dis. 1998 Jun;57(6):378-9 - PubMed
  6. Osteoporos Int. 2001;12(6):429-37 - PubMed
  7. J Reprod Med. 2003 Jun;48(6):425-34 - PubMed
  8. Curr Opin Rheumatol. 2002 Jul;14(4):441-6 - PubMed
  9. J Bone Miner Res. 2004 May;19(5):712-3 - PubMed
  10. Radiology. 2003 Feb;226(2):366-72 - PubMed
  11. N Engl J Med. 2001 May 10;344(19):1434-41 - PubMed
  12. Rheum Dis Clin North Am. 2001 Feb;27(1):255-62 - PubMed
  13. J Gerontol. 1994 Mar;49(2):M72-84 - PubMed
  14. Chang Gung Med J. 2000 Apr;23(4):197-204 - PubMed
  15. N Engl J Med. 2003 Sep 25;349(13):1216-26 - PubMed
  16. J Am Geriatr Soc. 1996 May;44(5):489-97 - PubMed
  17. J Bone Miner Res. 1995 Feb;10(2):175-7 - PubMed
  18. Arch Intern Med. 2002 Oct 28;162(19):2217-22 - PubMed
  19. J Bone Miner Res. 2001 Oct;16(10):1846-53 - PubMed
  20. Arch Intern Med. 2002 May 27;162(10):1140-3 - PubMed
  21. Lancet. 2005 May 7-13;365(9471):1621-8 - PubMed
  22. J Bone Miner Res. 1997 Jan;12(1):24-35 - PubMed
  23. BMJ. 1989 Oct 7;299(6704):889-92 - PubMed
  24. Clin Orthop Relat Res. 2003 Mar;(408):268-78 - PubMed
  25. N Engl J Med. 2001 Feb 1;344(5):333-40 - PubMed
  26. Ann Intern Med. 1990 Jan 15;112(2):96-101 - PubMed
  27. Ann Intern Med. 1998 May 15;128(10):793-800 - PubMed
  28. N Engl J Med. 1991 May 9;324(19):1326-31 - PubMed
  29. Br Med J. 1980 Jun 7;280(6228):1340-4 - PubMed
  30. Mayo Clin Proc. 2002 Apr;77(4):334-8 - PubMed
  31. Am J Med Sci. 1995 Dec;310(6):229-34 - PubMed
  32. JAMA. 2002 Jul 17;288(3):321-33 - PubMed
  33. J Rheumatol. 2001 Nov;28(11):2504-8 - PubMed
  34. J Clin Endocrinol Metab. 2000 Nov;85(11):4118-24 - PubMed
  35. Clin Orthop Relat Res. 2000 Mar;(372):139-50 - PubMed
  36. N Engl J Med. 2002 Feb 28;346(9):653-61 - PubMed
  37. J Clin Oncol. 2002 May 1;20(9):2382-7 - PubMed
  38. Eur Spine J. 2000 Oct;9(5):445-50 - PubMed
  39. J Bone Joint Surg Am. 2000 Aug;82(8):1063-70 - PubMed
  40. N Engl J Med. 2003 Sep 25;349(13):1207-15 - PubMed
  41. Maturitas. 1996 Aug;25(1):69-75 - PubMed
  42. JAMA. 1999 Oct 13;282(14):1344-52 - PubMed
  43. N Engl J Med. 2000 Nov 23;343(21):1506-13 - PubMed
  44. Arch Intern Med. 1996 Jul 22;156(14):1521-5 - PubMed
  45. JAMA. 2001 Jan 17;285(3):320-3 - PubMed
  46. JAMA. 2004 Apr 14;291(14):1701-12 - PubMed
  47. Osteoporos Int. 2003 Aug;14(8):672-6 - PubMed
  48. Endocrinol Metab Clin North Am. 2003 Mar;32(1):273-84 - PubMed
  49. Spine (Phila Pa 1976). 2001 Jul 15;26(14):1631-8 - PubMed
  50. BMJ. 1998 Aug 15;317(7156):465-8 - PubMed
  51. BMJ. 1994 Apr 23;308(6936):1081-2 - PubMed
  52. Clin Orthop Relat Res. 2004 Aug;(425):126-34 - PubMed
  53. Radiol Clin North Am. 1998 May;36(3):533-46 - PubMed
  54. Spine (Phila Pa 1976). 1999 Aug 1;24(15):1521-6 - PubMed
  55. J Bone Joint Surg Br. 2001 Sep;83(7):1069-74 - PubMed
  56. AJNR Am J Neuroradiol. 2001 Feb;22(2):373-81 - PubMed
  57. Geriatr Nurs. 1994 Jul-Aug;15(4):201-5; quiz 206 - PubMed
  58. Spine (Phila Pa 1976). 1997 Dec 15;22(24 Suppl):49S-57S - PubMed
  59. J Gerontol A Biol Sci Med Sci. 2000 Sep;55(9):M489-91 - PubMed
  60. Praxis (Bern 1994). 1999 Dec 9;88(50):2057-60 - PubMed
  61. Age Ageing. 2000 Jan;29(1):57-62 - PubMed
  62. J Bone Joint Surg Am. 2003 Dec;85(12):2294-302 - PubMed
  63. J Bone Joint Surg Am. 2002 Aug;84(8):1342-8 - PubMed
  64. BMJ. 2005 Apr 30;330(7498):1003 - PubMed
  65. Bone. 1995 Nov;17(5 Suppl):505S-511S - PubMed
  66. BMJ. 1988 Dec 3;297(6661):1443-6 - PubMed
  67. Osteoporos Int. 2002 Jul;13(7):560-4 - PubMed
  68. Clin Orthop Relat Res. 2003 Oct;(415 Suppl):S176-86 - PubMed
  69. South Med J. 2001 Jun;94(6):569-73 - PubMed
  70. J Clin Invest. 1999 Aug;104(4):439-46 - PubMed
  71. Endocr Rev. 2002 Aug;23(4):570-8 - PubMed
  72. N Engl J Med. 1992 Dec 3;327(23):1637-42 - PubMed
  73. Lancet. 1996 Dec 7;348(9041):1535-41 - PubMed
  74. N Engl J Med. 1995 Mar 23;332(12):767-73 - PubMed
  75. J Bone Joint Surg Am. 2005 Jan;87(1):3-7 - PubMed
  76. Osteoporos Int. 2001;12(9):794-9 - PubMed
  77. Lancet. 1980 Nov 29;2(8205):1151-4 - PubMed
  78. Am J Med. 1993 Jun;94(6):595-601 - PubMed
  79. Osteoporos Int. 2001;12(10):844-8 - PubMed
  80. J Clin Endocrinol Metab. 2000 May;85(5):1895-900 - PubMed
  81. Spine (Phila Pa 1976). 2002 Oct 1;27(19):2173-8; discussion 2178-9 - PubMed
  82. Spine (Phila Pa 1976). 1997 Dec 15;22(24 Suppl):2S-11S - PubMed
  83. Clin Orthop Relat Res. 1998 Mar;(348):10-4 - PubMed
  84. N Engl J Med. 1992 Aug 27;327(9):620-7 - PubMed
  85. Spine (Phila Pa 1976). 2003 Oct 1;28(19):2260-5; discussion 2265-7 - PubMed
  86. Clin Ther. 1999 Jun;21(6):1025-44 - PubMed
  87. Osteoporos Int. 1998;8(6):552-6 - PubMed
  88. J Neurosurg. 2003 Jan;98(1 Suppl):36-42 - PubMed
  89. Arch Phys Med Rehabil. 2001 May;82(5):608-12 - PubMed
  90. Ann Intern Med. 1992 Jul 1;117(1):1-9 - PubMed
  91. J Bone Miner Res. 1997 Jan;12(1):16-23 - PubMed
  92. Clin Imaging. 2002 Jan-Feb;26(1):1-5 - PubMed
  93. J Clin Endocrinol Metab. 2002 Oct;87(10):4528-35 - PubMed
  94. Osteoporos Int. 2000;11(1):83-91 - PubMed
  95. Osteoporos Int. 1999;9(5):461-8 - PubMed
  96. Bone. 2002 May;30(5 Suppl):67S-70S - PubMed

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