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Groen HC, Gijsen FJ, van der Lugt A, et al. High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81. Neth Heart J. 2008;16(7):280-3doi: 10.1007/BF03086163.
Groen, H. C., Gijsen, F. J., van der Lugt, A., Ferguson, M. S., Hatsukami, T. S., Yuan, C., van der Steen, A. F., & Wentzel, J. J. (2008). High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 16(7), 280-3. https://doi.org/10.1007/BF03086163
Groen, H C, et al. "High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 16,7 (2008): 280-3. doi: https://doi.org/10.1007/BF03086163
Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, Yuan C, van der Steen AF, Wentzel JJ. High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81. Neth Heart J. 2008 Aug;16(7):280-3. doi: 10.1007/BF03086163. PMID: 18711619; PMCID: PMC2516295.
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Neth Heart J. 2008 Aug;16(7):280-3. doi: 10.1007/BF03086163.

High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

H C Groen, F J H Gijsen, A van der Lugt, M S Ferguson, T S Hatsukami, C Yuan, A F W van der Steen, J J Wentzel

Affiliations

  1. Departments of Biomedical Engineering and Radiology, Erasmus MC, Rotterdam, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands.

PMID: 18711619 PMCID: PMC2516295 DOI: 10.1007/BF03086163

Abstract

Shear stress of the blood at the vessel wall plays an important role in many processes in the cardiovascular system primarily focused on the regulation of vessel lumen and wall dimensions. There is ample evidence that atherosclerotic plaques are generated at low shear stress regions in the cardiovascular system, while high shear stress regions are protected. In the course of plaque progression, advanced plaques start to encroach into the lumen, and thereby start to experience high shear stress at the endothelium. Until now the consequences of high shear stress working at the endothelium of an advanced plaque are unknown. As high shear stress influences tissue regression, we hypothesised that high shear stress can destabilise the plaque by cap weakening leading to ulceration. We investigated this hypothesis in a magnetic resonance imaging (MRI) dataset of a 67-year-old woman with a plaque in the carotid artery at baseline and an ulcer at ten-month follow-up. The lumen, plaque components (lipid/necrotic core, intraplaque haemorrhage) and ulcer were reconstructed three dimensionally and the geometry at baseline was used for shear stress calculation using computational fluid dynamics. Correlation of the change in plaque composition with the shear stress at baseline showed that the ulcer was generated exclusively at the high shear stress location. In this serial MRI study we found plaque ulceration at the high shear stress location of a protruding plaque in the carotid artery. Our data suggest that high shear stress influences plaque vulnerability and therefore may become a potential parameter for predicting future events. (Neth Heart J 2008;16:280-3.).

Keywords: magnetic resonance imaging; plaque vulnerability; shear stress

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