Display options
Cite
Burnham BS, Chen SY, Sood A, et al. Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents. Met Based Drugs. 1995;2(4):221-32doi: 10.1155/MBD.1995.221.
Burnham, B. S., Chen, S. Y., Sood, A., Spielvogel, B. F., & Hall, I. H. (1995). Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents. Metal-based drugs, 2(4), 221-32. https://doi.org/10.1155/MBD.1995.221
Burnham, B S, et al. "Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents." Metal-based drugs vol. 2,4 (1995): 221-32. doi: https://doi.org/10.1155/MBD.1995.221
Burnham BS, Chen SY, Sood A, Spielvogel BF, Hall IH. Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents. Met Based Drugs. 1995;2(4):221-32. doi: 10.1155/MBD.1995.221. PMID: 18472769; PMCID: PMC2364981.
Copy Download .nbib Format: NLM
Share it on

Met Based Drugs. 1995;2(4):221-32. doi: 10.1155/MBD.1995.221.

Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents.

Metal-based drugs

B S Burnham, S Y Chen, A Sood, B F Spielvogel, I H Hall

Affiliations

  1. Division of Medicinal Chemistry and Natural Products School of Pharmacy University of North Carolina Chapel Hill N.C. 27599-7360 USA.

PMID: 18472769 PMCID: PMC2364981 DOI: 10.1155/MBD.1995.221

Abstract

The amine-borane adducts of cyclohexylamine and toluidine were observed to be potent hypolipidemic agents in mice, I.P. and rats orally at 8 mg/kg/day lowering both serum cholesterol and triglyceride levels after 14-16 days. These compounds were able to lower tissue lipids including the cholesterol content of the aorta wall. The agents successfully lower VLDL- and LDL-cholesterol content while elevating HDL-cholesterol content significantly. The agents also modulate lipid regulatory enzyme activities in a manner to reduce liver lipid levels. These studies demonstrate that the nitrogen atom does not have to be apart of the aromatic ring as in heterocyclic-amine borane to afford good hypolipidemic activity in rodents.

Publication Types