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Shishkov S, Varadinova T, Bontchev P, et al. Complexes of zinc with picolinic and aspartic acids inactivate free varicella-zoster virions. Met Based Drugs. 1996;3(1):11-4doi: 10.1155/MBD.1996.11.
Shishkov, S., Varadinova, T., Bontchev, P., Nachev, C., & Michailova, E. (1996). Complexes of zinc with picolinic and aspartic acids inactivate free varicella-zoster virions. Metal-based drugs, 3(1), 11-4. https://doi.org/10.1155/MBD.1996.11
Shishkov, S, et al. "Complexes of zinc with picolinic and aspartic acids inactivate free varicella-zoster virions." Metal-based drugs vol. 3,1 (1996): 11-4. doi: https://doi.org/10.1155/MBD.1996.11
Shishkov S, Varadinova T, Bontchev P, Nachev C, Michailova E. Complexes of zinc with picolinic and aspartic acids inactivate free varicella-zoster virions. Met Based Drugs. 1996;3(1):11-4. doi: 10.1155/MBD.1996.11. PMID: 18472788; PMCID: PMC2364995.
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Met Based Drugs. 1996;3(1):11-4. doi: 10.1155/MBD.1996.11.

Complexes of zinc with picolinic and aspartic acids inactivate free varicella-zoster virions.

Metal-based drugs

S Shishkov, T Varadinova, P Bontchev, C Nachev, E Michailova

Affiliations

  1. Laboratory of Virology Faculty of Biology University of Sofia 8 Dragan Tzankov Blvd. Sofia 1421 Bulgaria.

PMID: 18472788 PMCID: PMC2364995 DOI: 10.1155/MBD.1996.11

Abstract

Zn(II) picolinate and aspartate, Zn(pic)(2) and Zn(asp)(2), have been shown to inhibit key steps of the replication of HSV-1. In the present study we describe the effect of Zn(pic)(2) and Zn(asp)(2) on the replication of VZV and on the infectivity of free virions. The experiments are done using BHK-21 cells, a clinical isolate of VZV and Zn-complexes in concentration of 10 muM. When Zn-complexes are present during the whole period of infection, the yield of infectious virus progeny decreases up to 98%. The infectivity of VZV is completely restored after the removal of zinc. The virucidal effect is manifested at the 2nd h of contact, when 90% of the virions are inactivated. The results show that both Zn(pic)(2) and Zn(asp)(2) specifically inactivate free VZV virions with no effect on viral replication.

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