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Supuran CT. Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide. Met Based Drugs. 1996;3(2):57-62doi: 10.1155/MBD.1996.57.
Supuran, C. T. (1996). Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide. Metal-based drugs, 3(2), 57-62. https://doi.org/10.1155/MBD.1996.57
Supuran, C T. "Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide." Metal-based drugs vol. 3,2 (1996): 57-62. doi: https://doi.org/10.1155/MBD.1996.57
Supuran CT. Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide. Met Based Drugs. 1996;3(2):57-62. doi: 10.1155/MBD.1996.57. PMID: 18472796; PMCID: PMC2365010.
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Met Based Drugs. 1996;3(2):57-62. doi: 10.1155/MBD.1996.57.

Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide.

Metal-based drugs

C T Supuran

Affiliations

  1. University of Florence Laboratory of Inorganic and Bioinorganic Chemistry Via Gino Capponi 7 Firenze I-50121 Italy.

PMID: 18472796 PMCID: PMC2365010 DOI: 10.1155/MBD.1996.57

Abstract

Cu(II) complexes of 1-[4-(3-ethyl-piperidine-2,6-dione)-3-yl]-phenyl-2,4,6-trisubstituted pyridinium perchlorates, containing alkyl, aryl and combinations of these two types of moieties in their molecule were synthesized and characterized by elemental analysis, spectroscopy, magnetic, thermogravimetric and conductimetric measurements. In these complexes, Cu(II) ions are in octahedral geometry with four water molecules occupying the equatorial coordination sites and the two organic ligands in deprotonated state the remaining axial ones. The donor atom of these ligands is constituted by the ionized nitrogen of the glutarimide moiety. The new derivatives possess weak inhibitory activity towards the zinc enzyme carbonic anhydrase.

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