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Rougier F, Cornu E, Gachard N, et al. Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells. Mediators Inflamm. 1997;6(3):233-5doi: 10.1080/09629359791730.
Rougier, F., Cornu, E., Gachard, N., Praloran, V., & Denizot, Y. (1997). Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells. Mediators of inflammation, 6(3), 233-5. https://doi.org/10.1080/09629359791730
Rougier, F, et al. "Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells." Mediators of inflammation vol. 6,3 (1997): 233-5. doi: https://doi.org/10.1080/09629359791730
Rougier F, Cornu E, Gachard N, Praloran V, Denizot Y. Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells. Mediators Inflamm. 1997;6(3):233-5. doi: 10.1080/09629359791730. PMID: 18472825; PMCID: PMC2365834.
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Mediators Inflamm. 1997;6(3):233-5. doi: 10.1080/09629359791730.

Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells.

Mediators of inflammation

F Rougier, E Cornu, N Gachard, V Praloran, Y Denizot

Affiliations

  1. Laboratoire d'Hématologie Expérimentale Faculté de Médecine 2 rue Dr. Marcland Limoges 87025 France.

PMID: 18472825 PMCID: PMC2365834 DOI: 10.1080/09629359791730

Abstract

This study reports that TNF-alpha is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1alpha, IL-1beta, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-alpha on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.

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