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Mealy K, Clooney A, Marks P, et al. Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis. Mediators Inflamm. 1997;6(1):69-72doi: 10.1080/09629359791965.
Mealy, K., Clooney, A., Marks, P., Hennessy, T., & Jackson, J. (1997). Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis. Mediators of inflammation, 6(1), 69-72. https://doi.org/10.1080/09629359791965
Mealy, K, et al. "Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis." Mediators of inflammation vol. 6,1 (1997): 69-72. doi: https://doi.org/10.1080/09629359791965
Mealy K, Clooney A, Marks P, Hennessy T, Jackson J. Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis. Mediators Inflamm. 1997;6(1):69-72. doi: 10.1080/09629359791965. PMID: 18472837; PMCID: PMC2365840.
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Mediators Inflamm. 1997;6(1):69-72. doi: 10.1080/09629359791965.

Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis.

Mediators of inflammation

K Mealy, A Clooney, P Marks, T Hennessy, J Jackson

Affiliations

  1. Department of Surgery Trinity College and St James's Hospital Dublin Ireland.

PMID: 18472837 PMCID: PMC2365840 DOI: 10.1080/09629359791965

Abstract

The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, alpha, beta and gamma globulin fractions on serum electrophoresis, complement C(3) and transferrin levels. Danazol increased the alpha1, alpha2 and beta1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis.

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