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Hall IH, Chen SY, Barnes BJ, et al. The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats. Met Based Drugs. 1999;6(3):143-7doi: 10.1155/MBD.1999.143.
Hall, I. H., Chen, S. Y., Barnes, B. J., & West, D. X. (1999). The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats. Metal-based drugs, 6(3), 143-7. https://doi.org/10.1155/MBD.1999.143
Hall, I H, et al. "The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats." Metal-based drugs vol. 6,3 (1999): 143-7. doi: https://doi.org/10.1155/MBD.1999.143
Hall IH, Chen SY, Barnes BJ, West DX. The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats. Met Based Drugs. 1999;6(3):143-7. doi: 10.1155/MBD.1999.143. PMID: 18472903; PMCID: PMC2366827.
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Met Based Drugs. 1999;6(3):143-7. doi: 10.1155/MBD.1999.143.

The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats.

Metal-based drugs

I H Hall, S Y Chen, B J Barnes, D X West

Affiliations

  1. Division of Medicinal Chemistry and Natural Products School of Pharmacy University of North Carolina Chapel Hill North Carolina 27599-7360 USA.

PMID: 18472903 PMCID: PMC2366827 DOI: 10.1155/MBD.1999.143

Abstract

Heterocyclic thiosemicarbazones, thioureas and their copper, nickel, and cobalt complexes were shown to be potent hypolipidemic agents in male Sprague Dawley rats at 8 mg/kg/day, orally. These agents lowered the activity of rat hepatic rate limiting enzymes for the synthesis of cholesterol and triglycerides. The effects of these agnets on cytoplasmic ATP-dependent citrate lyase, acetyl CoA synthetase and HMG-CoA reductase activities were reduced by a magnitude to explain the reduction of serum cholesterol levels afforded by the compounds. The reduction of acetyl CoA carboxylase, sn-glycerol-3-phosphate synthetase and phosphotidylate phosphohydrolase activities caused by the derivatives is of sufficient magnitude to explain the observed reduction in serum triglycerides after administration of the agents.

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