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Bjorling DE, Saban MR, Saban R. Neurogenic inflammation of Guinea-pig bladder. Mediators Inflamm. 1994;3(3):189-97doi: 10.1155/S0962935194000268.
Bjorling, D. E., Saban, M. R., & Saban, R. (1994). Neurogenic inflammation of Guinea-pig bladder. Mediators of inflammation, 3(3), 189-97. https://doi.org/10.1155/S0962935194000268
Bjorling, D E, et al. "Neurogenic inflammation of Guinea-pig bladder." Mediators of inflammation vol. 3,3 (1994): 189-97. doi: https://doi.org/10.1155/S0962935194000268
Bjorling DE, Saban MR, Saban R. Neurogenic inflammation of Guinea-pig bladder. Mediators Inflamm. 1994;3(3):189-97. doi: 10.1155/S0962935194000268. PMID: 18472941; PMCID: PMC2367033.
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Mediators Inflamm. 1994;3(3):189-97. doi: 10.1155/S0962935194000268.

Neurogenic inflammation of Guinea-pig bladder.

Mediators of inflammation

D E Bjorling, M R Saban, R Saban

Affiliations

  1. Smooth Muscle Laboratory Department of Surgical Sciences School of Veterinary Medicine University of Wisconsin Madison WI USA.

PMID: 18472941 PMCID: PMC2367033 DOI: 10.1155/S0962935194000268

Abstract

Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability. Histological changes after exposure to these compounds progressed with time from intense vasodilatation to marginalization of granulocytes followed by interstitial migration of leukocytes. In vitro incubation of guinea-pig bladder tissue with substance P and ovalbumin stimulated release of prostaglandin D(2) and leukotrienes. In vitro incubation of bladder tissue with capsaicin, OVA, prostaglandin D(2), leukotriene C(4), histamine, or calcium ionophore A-23587 all stimulated substance P release. These data suggest that bladder inflammation initiated by a variety of stimuli could lead to a cyclic pattern of release of inflammatory mediators and neuropeptides, which could result in amplification and persistence of cystitis after the inciting cause has subsided.

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