Display options
Cite
Peña F, Gutiérrez-Lerma A, Quiroz-Baez R, et al. The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr Neuropharmacol. 2006;4(2):149-63doi: 10.2174/157015906776359531.
Peña, F., Gutiérrez-Lerma, A., Quiroz-Baez, R., & Arias, C. (2006). The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Current neuropharmacology, 4(2), 149-63. https://doi.org/10.2174/157015906776359531
Peña, F, et al. "The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy." Current neuropharmacology vol. 4,2 (2006): 149-63. doi: https://doi.org/10.2174/157015906776359531
Peña F, Gutiérrez-Lerma A, Quiroz-Baez R, Arias C. The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr Neuropharmacol. 2006 Apr;4(2):149-63. doi: 10.2174/157015906776359531. PMID: 18615129; PMCID: PMC2430670.
Copy Download .nbib Format: NLM
Share it on

Curr Neuropharmacol. 2006 Apr;4(2):149-63. doi: 10.2174/157015906776359531.

The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy.

Current neuropharmacology

F Peña, Ai Gutiérrez-Lerma, R Quiroz-Baez, C Arias

Affiliations

  1. Departamento de Farmacobiología, Cinvestav-Coapa, México D.F. 14330, México. [email protected]

PMID: 18615129 PMCID: PMC2430670 DOI: 10.2174/157015906776359531

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of memory and other cognitive functions. Substantial evidence based on genetic, neuropathological and biochemical data has established the central role of beta-amyloid protein (betaAP) in this pathology. Although the precise etiology of AD is not well understood yet, strong evidence for some of the molecular events that lead to progressive brain dysfunction and neurodegeneration in AD has been afforded by identification of biochemical pathways implicated in the generation of betaAP, development of transgenic models exhibiting progressive disease pathology and by data on the effects of betaAP at the neuronal network level. However, the mechanisms by which betaAP causes cognitive decline have not been determined, nor is it clear if the degree of dementia correlates in time with the degree of neuronal loss. Hence, it is of interest to understand the biochemical processes involved in the mechanisms of betaAP-induced neurotoxicity and the mechanisms involved in electrophysiological effects of this protein on different parameters of synaptic transmission and on neuronal firing properties. In this review we analyze recent evidence suggesting a complex role of betaAP in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in AD as well as the therapeutic implications based on betaAP metabolism inhibition.

Keywords: Alzheimer disease; cognitive impairment; synaptic dysfunction; synaptic plasticity; β-amyloid protein

References

  1. Curr Med Chem. 2003 Dec;10(24):2651-9 - PubMed
  2. Science. 1990 Oct 12;250(4978):279-82 - PubMed
  3. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1317-21 - PubMed
  4. J Biol Chem. 2004 Jan 16;279(3):1942-9 - PubMed
  5. Int J Geriatr Psychiatry. 1999 Feb;14(2):135-46 - PubMed
  6. Neurobiol Dis. 1998 Oct;5(4):229-43 - PubMed
  7. Lancet. 1995 Dec 9;346(8989):1524-8 - PubMed
  8. Brain Res. 2005 Nov 16;1062(1-2):120-6 - PubMed
  9. J Neurosci. 1997 Feb 1;17(3):1046-54 - PubMed
  10. Pathol Res Pract. 1989 Nov;185(5):799-802 - PubMed
  11. Neuroscience. 2003;120(3):705-20 - PubMed
  12. Ann Neurol. 1991 Oct;30(4):572-80 - PubMed
  13. Neurobiol Dis. 2005 Nov;20(2):254-66 - PubMed
  14. J Neurosci. 1992 Feb;12(2):376-89 - PubMed
  15. Annu Rev Biochem. 1997;66:385-407 - PubMed
  16. Acta Neuropathol. 1983;60(1-2):113-24 - PubMed
  17. Neuron. 1997 Jun;18(6):839-42 - PubMed
  18. J Neurosci. 2000 Jun 1;20(11):4050-8 - PubMed
  19. Nature. 2001 Nov 8;414(6860):212-6 - PubMed
  20. Neurosci Lett. 2003 Dec 19;353(2):143-7 - PubMed
  21. J Neurophysiol. 2001 Sep;86(3):1312-20 - PubMed
  22. Nature. 2000 Sep 7;407(6800):48-54 - PubMed
  23. Eur J Pharmacol. 1999 Oct 15;382(3):167-75 - PubMed
  24. Neurosci Lett. 2004 Aug 19;366(3):320-5 - PubMed
  25. J Neurochem. 2004 Sep;90(6):1489-99 - PubMed
  26. Neurosci Lett. 1999 Nov 19;275(3):187-90 - PubMed
  27. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53 - PubMed
  28. Ann Neurol. 1997 Jan;41(1):17-24 - PubMed
  29. Nature. 1999 Jul 8;400(6740):173-7 - PubMed
  30. J Mol Biol. 2000 May 26;299(1):225-31 - PubMed
  31. Neurobiol Aging. 2005 Apr;26(4):419-28 - PubMed
  32. Brain Res. 2000 Sep 8;876(1-2):185-90 - PubMed
  33. Clin Neuropharmacol. 1991;14 Suppl 1:S9-14 - PubMed
  34. J Neurosci Res. 2000 Apr 1;60(1):65-72 - PubMed
  35. Methods Find Exp Clin Pharmacol. 1994 Mar;16(2):141-51 - PubMed
  36. Nature. 1999 Dec 2;402(6761):533-7 - PubMed
  37. Learn Mem. 2004 Jul-Aug;11(4):447-52 - PubMed
  38. Brain Res. 2005 May 31;1045(1-2):224-8 - PubMed
  39. Cell. 2005 Mar 11;120(5):701-13 - PubMed
  40. J Biol Chem. 2001 May 18;276(20):17301-6 - PubMed
  41. Neurochem Res. 2003 Nov;28(11):1705-13 - PubMed
  42. J Biol Chem. 2000 Feb 18;275(7):4713-8 - PubMed
  43. Neurology. 2001 Jan 9;56(1):127-9 - PubMed
  44. Brain Res. 2001 Aug 24;911(2):193-202 - PubMed
  45. J Membr Biol. 2004 Jan 1;197(1):33-48 - PubMed
  46. Acta Neurobiol Exp (Wars). 2004;64(1):71-9 - PubMed
  47. J Neurosci. 2001 Jan 1;21(1):RC120 - PubMed
  48. Neurosci Lett. 1999 Jan 15;259(3):165-8 - PubMed
  49. Science. 1999 Oct 22;286(5440):735-41 - PubMed
  50. J Neurochem. 1997 Jul;69(1):273-84 - PubMed
  51. Brain Res. 2003 Apr 11;968(2):263-72 - PubMed
  52. Neurosci Lett. 2000 Jul 14;288(2):119-22 - PubMed
  53. J Neurochem. 1996 May;66(5):2034-40 - PubMed
  54. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):742-7 - PubMed
  55. J Neurosci Res. 2002 Apr 1;68(1):89-96 - PubMed
  56. Nat Med. 2000 Aug;6(8):916-9 - PubMed
  57. J Biol Chem. 1999 Oct 15;274(42):30322-7 - PubMed
  58. Nature. 1993 Jan 7;361(6407):31-9 - PubMed
  59. Peptides. 2002 Jul;23(7):1311-5 - PubMed
  60. Neurobiol Learn Mem. 2002 May;77(3):354-71 - PubMed
  61. J Biol Chem. 1996 Feb 23;271(8):4077-81 - PubMed
  62. Neurobiol Dis. 2005 Nov;20(2):187-98 - PubMed
  63. Brain Res Brain Res Rev. 1998 May;26(2-3):360-78 - PubMed
  64. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6953-7 - PubMed
  65. Neurochem Int. 2004 Jul;45(1):31-8 - PubMed
  66. Neurobiol Aging. 1992 May-Jun;13(3):375-82 - PubMed
  67. J Neurosci. 2001 Aug 1;21(15):5703-14 - PubMed
  68. Neurobiol Aging. 1996 Nov-Dec;17(6):921-33 - PubMed
  69. Biophys J. 2004 Apr;86(4):2231-7 - PubMed
  70. Am J Pathol. 1991 Jan;138(1):235-46 - PubMed
  71. J Neurosci. 2001 Jun 15;21(12):4125-33 - PubMed
  72. J Neuropathol Exp Neurol. 1996 Oct;55(10):1023-5 - PubMed
  73. J Neurosci Res. 2002 Jul 1;69(1):10-23 - PubMed
  74. Annu Rev Neurosci. 1998;21:479-505 - PubMed
  75. J Biol Chem. 1999 Sep 3;274(36):25945-52 - PubMed
  76. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13217-21 - PubMed
  77. Eur J Pharmacol. 1995 Sep 25;284(3):R1-3 - PubMed
  78. Neuron. 2004 Sep 30;44(1):181-93 - PubMed
  79. Nature. 1988 Feb 11;331(6156):528-30 - PubMed
  80. Nature. 2002 Apr 4;416(6880):535-9 - PubMed
  81. Neurobiol Aging. 1995 May-Jun;16(3):285-98; discussion 298-304 - PubMed
  82. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3922-7 - PubMed
  83. J Neuropathol Exp Neurol. 1997 Aug;56(8):933-44 - PubMed
  84. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71 - PubMed
  85. J Neurosci. 2001 Jul 1;21(13):4691-8 - PubMed
  86. Biophys J. 1997 Jul;73(1):67-75 - PubMed
  87. Brain Res. 1999 Sep 4;840(1-2):23-35 - PubMed
  88. Science. 1987 Feb 20;235(4791):880-4 - PubMed
  89. J Neurochem. 1997 Jan;68(1):265-71 - PubMed
  90. J Membr Biol. 2004 Nov;202(1):1-10 - PubMed
  91. Arch Neurol. 2003 Aug;60(8):1119-22 - PubMed
  92. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):919-24 - PubMed
  93. J Neurosci Res. 1995 Jul 1;41(4):561-6 - PubMed
  94. J Neurosci. 2004 May 12;24(19):4535-40 - PubMed
  95. J Neurochem. 2001 Mar;76(6):1895-904 - PubMed
  96. J Neurosci. 1993 Apr;13(4):1676-87 - PubMed
  97. Exp Neurol. 2002 Jul;176(1):163-74 - PubMed
  98. Biochem Biophys Res Commun. 1984 Aug 16;122(3):1131-5 - PubMed
  99. Neurobiol Dis. 1999 Feb;6(1):56-62 - PubMed
  100. Neuron. 1991 Apr;6(4):487-98 - PubMed
  101. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5 - PubMed
  102. FASEB J. 2001 Nov;15(13):2433-44 - PubMed
  103. Brain Res. 2002 Nov 29;956(2):254-61 - PubMed
  104. JAMA. 2000 Mar 22-29;283(12):1571-7 - PubMed
  105. Trends Neurosci. 1997 Feb;20(2):67-72 - PubMed
  106. J Neurochem. 2001 Nov;79(3):699-712 - PubMed
  107. J Physiol. 2002 Jun 15;541(Pt 3):1013-23 - PubMed
  108. Nat Neurosci. 2005 Jan;8(1):79-84 - PubMed
  109. Science. 1992 Oct 2;258(5079):126-9 - PubMed
  110. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12243-7 - PubMed
  111. Nature. 2000 Jun 8;405(6787):689-94 - PubMed
  112. J Neurochem. 2002 Jun;81(5):1011-20 - PubMed
  113. Neuroreport. 1996 Dec 20;8(1):87-92 - PubMed
  114. J Neurocytol. 2004 May;33(3):377-87 - PubMed
  115. Neurobiol Dis. 2003 Aug;13(3):177-90 - PubMed
  116. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7141-6 - PubMed
  117. Biochemistry. 2003 Nov 11;42(44):12749-60 - PubMed
  118. J Neurosci. 2005 Aug 3;25(31):7278-87 - PubMed
  119. Acta Pharmacol Sin. 2004 Feb;25(2):181-5 - PubMed
  120. Curr Opin Neurobiol. 2002 Apr;12(2):211-6 - PubMed
  121. Biochemistry. 1998 Feb 10;37(6):1680-5 - PubMed
  122. Nat Neurosci. 2005 Aug;8(8):1051-8 - PubMed
  123. Neurosci Lett. 2001 Mar 9;300(2):67-70 - PubMed
  124. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5274-9 - PubMed
  125. Nat Rev Neurosci. 2001 Aug;2(8):595-8 - PubMed
  126. J Neurochem. 1998 May;70(5):2179-87 - PubMed
  127. Biochem Biophys Res Commun. 2003 Jan 31;301(1):231-5 - PubMed
  128. Biochemistry. 1993 May 11;32(18):4693-7 - PubMed
  129. EMBO J. 1985 Nov;4(11):2757-63 - PubMed
  130. J Neuropathol Exp Neurol. 1997 May;56(5):531-40 - PubMed
  131. Nat Neurosci. 2004 Nov;7(11):1181-3 - PubMed
  132. J Neurosci. 2004 May 12;24(19):4692-7 - PubMed
  133. J Neurosci. 1999 Oct 15;19(20):8876-84 - PubMed
  134. Neurobiol Aging. 2005 Mar;26(3):355-61 - PubMed
  135. Neuron. 2003 Mar 27;37(6):925-37 - PubMed
  136. J Neurosci. 2005 Jul 20;25(29):6887-97 - PubMed
  137. Am J Pathol. 1999 Sep;155(3):853-62 - PubMed
  138. Science. 1998 Nov 13;282(5392):1281-4 - PubMed
  139. J Neurochem. 2004 Nov;91(3):547-57 - PubMed
  140. Neurobiol Aging. 1992 Sep-Oct;13(5):587-90 - PubMed
  141. J Neurochem. 2001 Jan;76(1):1-10 - PubMed
  142. Ann Neurol. 1990 May;27(5):457-64 - PubMed
  143. J Neurol Sci. 1987 Apr;78(2):151-64 - PubMed
  144. Int J Immunopharmacol. 1999 Mar;21(3):219-25 - PubMed
  145. Dev Cell. 2002 Jul;3(1):85-97 - PubMed
  146. J Neurosci. 2002 May 1;22(9):3445-53 - PubMed
  147. Neurobiol Dis. 1998 Aug;5(2):81-8 - PubMed
  148. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3228-33 - PubMed
  149. Neurobiol Dis. 2003 Mar;12(2):97-109 - PubMed
  150. Neuroscience. 2004;129(3):583-92 - PubMed
  151. J Psychiatry Neurosci. 2004 Nov;29(6):427-41 - PubMed
  152. Alzheimer Dis Assoc Disord. 1998 Mar;12(1):14-7 - PubMed
  153. Brain Res. 2005 Jan 21;1031(2):222-8 - PubMed
  154. Trends Neurosci. 1997 Dec;20(12):558-9 - PubMed
  155. Curr Opin Neurobiol. 2004 Dec;14(6):665-74 - PubMed
  156. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20 - PubMed
  157. Neuroreport. 1995 Nov 27;6(17):2409-13 - PubMed
  158. Science. 1996 Oct 4;274(5284):99-102 - PubMed
  159. Am J Pathol. 1990 Dec;137(6):1293-7 - PubMed
  160. Neuroscience. 2000;95(1):1-4 - PubMed
  161. Brain Res. 2002 Jan 11;924(2):133-40 - PubMed
  162. Brain Res. 2003 Jul 4;977(1):16-22 - PubMed
  163. Ann N Y Acad Sci. 1994 Dec 15;747:245-55 - PubMed
  164. Hippocampus. 2002;12(1):86-104 - PubMed
  165. FASEB J. 2005 Jan;19(1):150-2 - PubMed
  166. Science. 1997 Oct 3;278(5335):114-7 - PubMed
  167. J Neurophysiol. 2002 May;87(5):2441-9 - PubMed
  168. Biochem Biophys Res Commun. 2002 May 17;293(4):1197-203 - PubMed
  169. Neuroreport. 1997 Oct 20;8(15):3213-7 - PubMed
  170. Proc Natl Acad Sci U S A. 1986 Jan;83(2):503-7 - PubMed
  171. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):617-20 - PubMed
  172. J Neurophysiol. 2001 Feb;85(2):708-13 - PubMed
  173. J Biol Chem. 1999 Mar 5;274(10):6483-92 - PubMed
  174. Ann Neurol. 1999 Dec;46(6):860-6 - PubMed
  175. J Neurochem. 1993 Nov;61(5):1965-8 - PubMed
  176. J Neurosci. 2004 Mar 31;24(13):3370-8 - PubMed
  177. J Neurobiol. 1998 Jan;34(1):69-82 - PubMed
  178. Hippocampus. 2005;15(1):110-7 - PubMed
  179. Neurodegeneration. 1996 Dec;5(4):417-21 - PubMed
  180. J Neurosci. 2004 Nov 10;24(45):10191-200 - PubMed
  181. Brain Res. 1999 Feb 6;818(1):168-70 - PubMed
  182. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1710-5 - PubMed
  183. Neurology. 2002 Oct 22;59(8):1257-8 - PubMed
  184. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10417-22 - PubMed
  185. Science. 1987 Feb 20;235(4791):877-80 - PubMed
  186. J Neurosci. 2001 Feb 15;21(4):1327-33 - PubMed
  187. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10573-7 - PubMed
  188. Development. 1997 Dec;124(23):4759-67 - PubMed
  189. Trends Pharmacol Sci. 1991 Oct;12(10):383-8 - PubMed
  190. Neurobiol Aging. 2000 Mar-Apr;21(2):321-30 - PubMed
  191. J Biol Chem. 1996 Aug 23;271(34):20631-5 - PubMed
  192. Mol Cell Neurosci. 2005 May;29(1):65-73 - PubMed
  193. Nat Cell Biol. 2001 May;3(5):507-11 - PubMed
  194. Brain Res. 1991 Nov 1;563(1-2):311-4 - PubMed
  195. Neurosci Lett. 1993 Mar 5;151(1):111-4 - PubMed
  196. Neuroreport. 1999 May 14;10(7):1427-31 - PubMed
  197. Int J Psychophysiol. 2000 Mar;35(2-3):95-124 - PubMed
  198. Biochem Biophys Res Commun. 2002 May 17;293(4):1204-8 - PubMed
  199. J Physiol. 2003 Feb 15;547(Pt 1):147-57 - PubMed
  200. Anal Biochem. 2004 Dec 1;335(1):81-90 - PubMed
  201. Science. 2000 Oct 6;290(5489):150-3 - PubMed
  202. J Neurosci. 2005 Mar 9;25(10):2455-62 - PubMed
  203. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5191-3 - PubMed
  204. Nat Neurosci. 1999 Mar;2(3):271-6 - PubMed

Publication Types