Display options
Cite
Nojiri S, Nakao H, Sugauchi F, et al. Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection. Hepatol Res. 2008;39(1):21-30doi: 10.1111/j.1872-034X.2008.00406.x.
Nojiri, S., Nakao, H., Sugauchi, F., Miyaki, T., Senda, K., Sasaki, M., Kataoka, H., Kamiya, T., Nakazawa, T., Ohara, H., Orito, E., & Joh, T. (2009). Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection. Hepatology research : the official journal of the Japan Society of Hepatology, 39(1), 21-30. https://doi.org/10.1111/j.1872-034X.2008.00406.x
Nojiri, Shunsuke, et al. "Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection." Hepatology research : the official journal of the Japan Society of Hepatology vol. 39,1 (2009): 21-30. doi: https://doi.org/10.1111/j.1872-034X.2008.00406.x
Nojiri S, Nakao H, Sugauchi F, Miyaki T, Senda K, Sasaki M, Kataoka H, Kamiya T, Nakazawa T, Ohara H, Orito E, Joh T. Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection. Hepatol Res. 2009 Jan;39(1):21-30. doi: 10.1111/j.1872-034X.2008.00406.x. Epub 2008 Aug 19. PMID: 18721155.
Copy Download .nbib Format: NLM
Share it on

Hepatol Res. 2009 Jan;39(1):21-30. doi: 10.1111/j.1872-034X.2008.00406.x. Epub 2008 Aug 19.

Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection.

Hepatology research : the official journal of the Japan Society of Hepatology

Shunsuke Nojiri, Haruhisa Nakao, Fuminaka Sugauchi, Tomokatsu Miyaki, Katsuhiro Senda, Makoto Sasaki, Hiromi Kataoka, Takeshi Kamiya, Takahiro Nakazawa, Hirotaka Ohara, Etsuro Orito, Takashi Joh

Affiliations

  1. Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

PMID: 18721155 DOI: 10.1111/j.1872-034X.2008.00406.x

Abstract

AIM: Many reports have revealed ursodeoxycholic acid (UDCA) to be effective against chronic hepatitis C virus (HCV). However, some cases resist this therapy and the mechanism of action remains unclear. In this study, UDCA was administered to patients with chronic HCV and the correlation between the bile acids of the biliary bile and serum and the drug efficacy was investigated.

METHODS: Fifteen patients were given 600 mg/day of UDCA for more than 24 weeks. The serum bile acid concentrations and biliary and serum bile acid were collected before and after 24 weeks of UDCA treatment, and composition determined by high-performance liquid chromatography.

RESULTS: The treatment was effective in nine cases (ALT decreased to less than twice the normal values 80 IU/L) and ineffective in six cases. There was no significant difference in the serum bile acid concentrations before and after UDCA treatment between the values of both cases. After UDCA treatment, the serum percentage of UDCA (effective, 62.5 +/- 2.0; ineffective, 53.5 +/- 2.5, (P = 0.02)) and the percentage of chenodeoxycholic acid (CDCA) showed no remarkable changes. In the biliary bile the percentage of CDCA (effective, 30.9 +/- 2.0; ineffective, 20.0 +/- 3.0, (P = 0.007)) and the percentage of UDCA showed no remarkable changes.

CONCLUSION: In the effective cases, the percentage of UDCA in the serum and the percentage of CDCA in biliary bile were significantly higher than in the ineffective cases. This indicates that, when effective, CDCA decreases in hepatocytes and this reduction contributes to hepatoprotection.

Publication Types