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Trincone A, Lama L, Lanzotti V, et al. Asymmetric reduction of ketones with resting cells of Sulfolobus solfataricus. Biotechnol Bioeng. 1990;35(6):559-64doi: 10.1002/bit.260350603.
Trincone, A., Lama, L., Lanzotti, V., Nicolaus, B., De Rosa, M., Rossi, M., & Gambacorta, A. (1990). Asymmetric reduction of ketones with resting cells of Sulfolobus solfataricus. Biotechnology and bioengineering, 35(6), 559-64. https://doi.org/10.1002/bit.260350603
Trincone, A, et al. "Asymmetric reduction of ketones with resting cells of Sulfolobus solfataricus." Biotechnology and bioengineering vol. 35,6 (1990): 559-64. doi: https://doi.org/10.1002/bit.260350603
Trincone A, Lama L, Lanzotti V, Nicolaus B, De Rosa M, Rossi M, Gambacorta A. Asymmetric reduction of ketones with resting cells of Sulfolobus solfataricus. Biotechnol Bioeng. 1990 Mar 15;35(6):559-64. doi: 10.1002/bit.260350603. PMID: 18592551.
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Biotechnol Bioeng. 1990 Mar 15;35(6):559-64. doi: 10.1002/bit.260350603.

Asymmetric reduction of ketones with resting cells of Sulfolobus solfataricus.

Biotechnology and bioengineering

A Trincone, L Lama, V Lanzotti, B Nicolaus, M De Rosa, M Rossi, A Gambacorta

Affiliations

  1. Istituto per la Chimica di Molecole di Interesse Biologico, Naples, Italy.

PMID: 18592551 DOI: 10.1002/bit.260350603

Abstract

The method of resting cells has been of interest in the development of biocatalysts applied to organic reactions.This article deals with the use of resting cells of a thermophilic archaebacterium Sulfolobus solfataricus, in the asymmetric reduction of acyclic, cyclic, and aromatic ketones. The system allows the continuous regeneration of endogenous coenzyme with the coupled substrate approach. The results indicate that the direction of hydride attack was equatorial on the re face of the carbonyl group of substrates producing (S)-alcohols with a good optical yield. A convenient system for the reuse of resting cells has been set out to synthesize (S)-alcohols on a preparative scale.

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