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Umemura T, Nakamura H, Goryo M, et al. Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks. Avian Pathol. 1984;13(4):743-51doi: 10.1080/03079458408418571.
Umemura, T., Nakamura, H., Goryo, M., & Itakura, C. (1984). Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks. Avian pathology : journal of the W.V.P.A, 13(4), 743-51. https://doi.org/10.1080/03079458408418571
Umemura, T, et al. "Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks." Avian pathology : journal of the W.V.P.A vol. 13,4 (1984): 743-51. doi: https://doi.org/10.1080/03079458408418571
Umemura T, Nakamura H, Goryo M, Itakura C. Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks. Avian Pathol. 1984 Oct;13(4):743-51. doi: 10.1080/03079458408418571. PMID: 18766884.
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Avian Pathol. 1984 Oct;13(4):743-51. doi: 10.1080/03079458408418571.

Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks.

Avian pathology : journal of the W.V.P.A

T Umemura, H Nakamura, M Goryo, C Itakura

Affiliations

  1. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Koyama, Tottori, Japan.

PMID: 18766884 DOI: 10.1080/03079458408418571

Abstract

Light microscopical and ultrastructural changes of skeletal muscles were described in chicks treated with monensin and oleandomycin in the food and water for 3 to 6 days. Simultaneously, or slightly subsequent to necrosis of some myofibres on days 3 and 4 of treatment, many myofibres exhibited reversible alterations initiated by focal myofibrillar lysis and degeneration of mitochondria. Reparative changes appearing on day 6 of treatment showed proliferation of the mitochondria, marked increase of ribosomes and polysomes, and enlargement of the Golgi apparatus in the sarcoplasm of degenerated myofibres. The morphological findings of monensin-oleandomycin myopathy in chicks were indistinguishable from monensin-tiamulin myopathy. Possible factors contributing to the unique morphology of this myopathy were discussed.

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