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Marazziti D, Dell'Osso B, Baroni S, et al. Changes in peripheral benzodiazepine receptors in patients with bipolar disorder. Neuropsychiatr Dis Treat. 2005;1(2):151-4doi: 10.2147/nedt.1.2.151.61046.
Marazziti, D., Dell'Osso, B., Baroni, S., Masala, I., Nasso, E. D., Giannaccini, G., & Dell'Osso, L. (2005). Changes in peripheral benzodiazepine receptors in patients with bipolar disorder. Neuropsychiatric disease and treatment, 1(2), 151-4. https://doi.org/10.2147/nedt.1.2.151.61046
Marazziti, Donatella, et al. "Changes in peripheral benzodiazepine receptors in patients with bipolar disorder." Neuropsychiatric disease and treatment vol. 1,2 (2005): 151-4. doi: https://doi.org/10.2147/nedt.1.2.151.61046
Marazziti D, Dell'Osso B, Baroni S, Masala I, Nasso ED, Giannaccini G, Dell'Osso L. Changes in peripheral benzodiazepine receptors in patients with bipolar disorder. Neuropsychiatr Dis Treat. 2005 Jun;1(2):151-4. doi: 10.2147/nedt.1.2.151.61046. PMID: 18568060; PMCID: PMC2413195.
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Neuropsychiatr Dis Treat. 2005 Jun;1(2):151-4. doi: 10.2147/nedt.1.2.151.61046.

Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

Neuropsychiatric disease and treatment

Donatella Marazziti, Bernardo Dell'Osso, Stefano Baroni, Irene Masala, Elena Di Nasso, Gino Giannaccini, Liliana Dell'Osso

Affiliations

  1. Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie University of Pisa Pisa, Italy. [email protected]

PMID: 18568060 PMCID: PMC2413195 DOI: 10.2147/nedt.1.2.151.61046

Abstract

Peripheral benzodiazepine (BDZ) receptors were investigated by means of the binding of the specific ligand (3)H-PK 11195 to platelet membranes in patients suffering from bipolar disorder and in healthy controls. The results showed that the density (Bmax) of peripheral BDZ receptors was significantly higher in patients than in control subjects, with no change in the dissociation constant. No correlation with demographic or clinical features was observed. These findings would suggest that alterations of peripheral BDZ receptors are present in patients suffering from bipolar disorder, but it is premature to conclude whether they may be related to the pathophysiology of the disorder, or are secondary to changes occurring in other systems, such as those regulating the stress response.

Keywords: 3H-PK 11195; benzodiazepine receptors; bipolar disorder; mitochondria; peripheral benzodiazepine receptors

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