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Seufert S, Coras R, Tränkle C, et al. PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Res. 2008;2008:513943doi: 10.1155/2008/513943.
Seufert, S., Coras, R., Tränkle, C., Zlotos, D. P., Blümcke, I., Tatenhorst, L., Heneka, M. T., & Hahnen, E. (2008). PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR research, 2008513943. https://doi.org/10.1155/2008/513943
Seufert, Sebastian, et al. "PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion." PPAR research vol. 2008 (2008): 513943. doi: https://doi.org/10.1155/2008/513943
Seufert S, Coras R, Tränkle C, Zlotos DP, Blümcke I, Tatenhorst L, Heneka MT, Hahnen E. PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Res. 2008;2008:513943. doi: 10.1155/2008/513943. PMID: 18815619; PMCID: PMC2542841.
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PPAR Res. 2008;2008:513943. doi: 10.1155/2008/513943.

PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.

PPAR research

Sebastian Seufert, Roland Coras, Christian Tränkle, Darius P Zlotos, Ingmar Blümcke, Lars Tatenhorst, Michael T Heneka, Eric Hahnen

Affiliations

  1. Institute of Human Genetics, Institute of Genetics, and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Street 34, 50931 Cologne, Germany.

PMID: 18815619 PMCID: PMC2542841 DOI: 10.1155/2008/513943

Abstract

Today, there is increasing evidence that PPARgamma agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARgamma activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARgamma inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARgamma independent manner.

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