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Ther Clin Risk Manag. 2008 Apr;4(2):353-61. doi: 10.2147/tcrm.s1266.

New treatment options in allergic rhinitis: patient considerations and the role of ciclesonide.

Therapeutics and clinical risk management

F Braido, C Lagasio, Img Piroddi, I Baiardini, Gw Canonica

Affiliations

  1. Allergy and Respiratory Diseases Department, University of Genoa Italy.

PMID: 18728855 PMCID: PMC2504079 DOI: 10.2147/tcrm.s1266

Abstract

Allergic rhinitis (AR) is a chronic inflammatory respiratory disease affecting 5%-50% of the worldwide population and its prevalence is increasing (Herman 2007). In addition, AR is associated with asthma and other co-morbidities such as conjunctivitis and sinusitis. The main symptoms are nasal congestion, rhinorrea, sneezing, itching, and post-nasal drainage induced after allergen exposure by an IgE-mediated inflammation of the membranes lining the nose. AR is not a life-threatening disease, but it has been shown to have a significant impact on quality of life. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines propose a classification of AR in intermittent and persistent, each graded as mild or moderate-severe, and provide a stepwise approach to the treatment. Inhaled steroids and antihistamine are the main tools in AR therapy but more safe and effective drugs are, however, needed. Inhaled steroid ciclesonide appears to be safe and effective.

Keywords: allergic rhinitis; asthma; ciclesonide; quality of life

References

  1. Allergy Asthma Proc. 1999 May-Jun;20(3):167-72 - PubMed
  2. J Allergy Clin Immunol. 1996 Aug;98(2):274-82 - PubMed
  3. Ann Allergy Asthma Immunol. 2007 Feb;98(2):175-81 - PubMed
  4. Science. 1993 Feb 19;259(5098):1132-3 - PubMed
  5. J Allergy Clin Immunol. 2002 Jul;110(1):68-71 - PubMed
  6. J Fam Pract. 1994 Feb;38(2):145-52 - PubMed
  7. Ann Allergy Asthma Immunol. 2006 Nov;97(5):657-63 - PubMed
  8. Curr Allergy Asthma Rep. 2004 May;4(3):237-44 - PubMed
  9. J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):39-44 - PubMed
  10. JAMA. 1995 Jul 12;274(2):161-4 - PubMed
  11. Thorax. 1991 Dec;46(12):891-4 - PubMed
  12. J Clin Pharmacol. 2006 Apr;46(4):461-7 - PubMed
  13. J Allergy Clin Immunol. 2000 Mar;105(3):489-94 - PubMed
  14. Pneumologie. 2005 Oct;59(10):689-95 - PubMed
  15. Allergy. 1986 Feb;41(2):118-24 - PubMed
  16. Allergy. 2003 Apr;58(4):284-6 - PubMed
  17. Allergy. 2000 Jan;55(1):16-33 - PubMed
  18. Ann Allergy Asthma Immunol. 2000 Oct;85(4):279-83 - PubMed
  19. Pulm Pharmacol Ther. 2005;18(6):390-6 - PubMed
  20. Ann Allergy. 1991 Sep;67(3):332-8 - PubMed
  21. Endocr Rev. 1990 May;11(2):201-20 - PubMed
  22. J Allergy Clin Immunol. 2006 Nov;118(5):1142-8 - PubMed
  23. Eur Respir J. 1995 Jul;8(7):1214-21 - PubMed
  24. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 2):S14-7 - PubMed
  25. J Investig Allergol Clin Immunol. 2002;12(3):204-10 - PubMed
  26. Ann Allergy Asthma Immunol. 1996 Oct;77(4):277-81 - PubMed
  27. Ann Allergy Asthma Immunol. 2003 Apr;90(4):416-21 - PubMed
  28. J Allergy Clin Immunol. 1996 Jan;97(1 Pt 2):169-76 - PubMed
  29. Allergy Asthma Proc. 1998 Sep-Oct;19(5):285-94 - PubMed
  30. Ann Allergy Asthma Immunol. 2000 Apr;84(4):403-10 - PubMed
  31. Clin Ther. 1995 Mar-Apr;17(2):252-63 - PubMed
  32. Trends Pharmacol Sci. 1993 Dec;14(12):436-41 - PubMed
  33. Am J Respir Crit Care Med. 1996 Nov;154(5):1505-10 - PubMed
  34. N Engl J Med. 1995 Mar 30;332(13):868-75 - PubMed
  35. J Pharm Pharmacol. 1984 Nov;36(11):763-5 - PubMed
  36. Int Arch Allergy Immunol. 2007;143(3):163-9 - PubMed
  37. Allergy Asthma Proc. 2003 Sep-Oct;24(5):323-9 - PubMed
  38. Ann Allergy Asthma Immunol. 2003 Aug;91(2):182-8 - PubMed
  39. Ann Allergy Asthma Immunol. 2005 Dec;95(6):525-9 - PubMed
  40. Acta Paediatr. 1992 Feb;81(2):100-2 - PubMed
  41. Clin Exp Allergy. 2004 Jun;34(6):952-7 - PubMed
  42. Allergy. 1999 Jan;54(1):64-9 - PubMed
  43. Am J Manag Care. 2002 Sep;8(13 Suppl):S335-40 - PubMed
  44. Clin Exp Allergy. 2005 Mar;35(3):288-98 - PubMed
  45. Mol Endocrinol. 1993 Jan;7(1):4-11 - PubMed
  46. Clin Exp Allergy. 2002 Sep;32(9):1310-5 - PubMed
  47. Ann Allergy. 1994 Aug;73(2):147-53 - PubMed
  48. Arch Otolaryngol Head Neck Surg. 2005 Mar;131(3):223-8 - PubMed
  49. Thorax. 1990 Oct;45(10):736-9 - PubMed
  50. J Allergy Clin Immunol. 1996 Jan;97(1 Pt 2):159-68 - PubMed
  51. Am J Rhinol. 2007 Jan-Feb;21(1):70-9 - PubMed
  52. Eur J Respir Dis Suppl. 1982;122:143-53 - PubMed
  53. Psychosomatics. 1999 Nov-Dec;40(6):491-6 - PubMed
  54. J Allergy Clin Immunol. 2000 Aug;106(2):253-9 - PubMed
  55. Thorax. 1995 Feb;50(2):105-10 - PubMed
  56. J Clin Pharmacol. 1999 Oct;39(10):1062-9 - PubMed
  57. Respir Med. 1996 Feb;90(2):69-77 - PubMed
  58. Clin Ther. 1999 Oct;21(10):1749-55 - PubMed
  59. Ann Allergy Asthma Immunol. 2006 Aug;97(2):149-57 - PubMed
  60. Eur Respir J. 2004 Mar;23(3):414-8 - PubMed
  61. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S45-53 - PubMed
  62. Ann Pharmacother. 2005 Dec;39(12):1984-9 - PubMed
  63. Ann Allergy Asthma Immunol. 1997 Jul;79(1):51-6 - PubMed
  64. J Allergy Clin Immunol. 1995 Jun;95(6):1172-8 - PubMed
  65. J Allergy Clin Immunol. 2005 Mar;115(3):459-65 - PubMed
  66. Clin Exp Allergy. 2004 Jul;34(7):1079-85 - PubMed
  67. Thorax. 1991 Oct;46(10):712-6 - PubMed
  68. Am Rev Respir Dis. 1984 May;129(5):723-9 - PubMed
  69. J Allergy Clin Immunol. 2004 Sep;114(3):527-30 - PubMed
  70. BMC Fam Pract. 2002 Aug 05;3:14 - PubMed
  71. Eur J Respir Dis. 1987 Feb;70(2):93-8 - PubMed
  72. Ann Allergy Asthma Immunol. 2003 Aug;91(2):160-7 - PubMed
  73. Psychosom Med. 2002 Jul-Aug;64(4):684-91 - PubMed
  74. Ann Allergy Asthma Immunol. 2003 Jul;91(1):44-8 - PubMed

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