Int J Clin Exp Pathol. 2008 Jan 01;1(5):396-402.

Fibrosing cholestatic hepatitis: clinicopathologic spectrum, diagnosis and pathogenesis.

International journal of clinical and experimental pathology

Shu-Yuan Xiao, Liang Lu, Hanlin L Wang

PMID: 18787628 PMCID: PMC2480579

Abstract

Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are under immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and periportal and pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be considered in differential diagnosis, and our current understanding of pathogenesis of this disease.

Keywords: Viral hepatitis; hepatitis B virus; hepatitis C virus; liver transplantation; pathogenesis

References

1. Hepatology. 1991 Apr;13(4):619-26 - PubMed
2. Hepatology. 1995 Jan;21(1):14-8 - PubMed
3. Am J Kidney Dis. 2006 Feb;47(2):309-16 - PubMed
4. Gastroenterology. 1992 Oct;103(4):1307-12 - PubMed
5. Transplantation. 1996 Feb 15;61(3):378-81 - PubMed
6. Br Med J (Clin Res Ed). 1984 May 26;288(6430):1563-6 - PubMed
7. J Hepatol. 1992 Jan;14(1):104-11 - PubMed
8. Hepatology. 1996 May;23(5):971-6 - PubMed
9. Am J Transplant. 2006 Dec;6(12):2983-93 - PubMed
10. Gastroenterology. 1997 Dec;113(6):1976-82 - PubMed
11. Transplantation. 1998 Nov 15;66(9):1254-8 - PubMed
12. J Am Soc Nephrol. 1998 Jun;9(6):1109-13 - PubMed
13. J Hepatol. 1987 Feb;4(1):37-44 - PubMed
14. Transplantation. 2002 Aug 27;74(4):427-37 - PubMed
15. Gastroenterology. 1992 Mar;102(3):956-62 - PubMed
16. Transplantation. 2002 Jan 15;73(1):56-63 - PubMed
17. Am J Pathol. 1990 Sep;137(3):667-76 - PubMed
18. Hepatology. 1991 Jan;13(1):150-7 - PubMed
19. Liver Transpl Surg. 1999 Jul;5(4):294-300 - PubMed
20. Am J Gastroenterol. 2002 Feb;97(2):478-83 - PubMed
21. Transplantation. 2006 Jun 27;81(12):1747-9 - PubMed
22. J Infect Dis. 2001 May 15;183(10):1437-44 - PubMed
23. Lancet. 1993 Nov 6;342(8880):1175 - PubMed
24. J Heart Lung Transplant. 1999 Jun;18(6):607-10 - PubMed
25. Transplantation. 1997 Sep 27;64(6):926-8 - PubMed
26. Hepatology. 1999 Dec;30(6):1513-20 - PubMed
27. Liver. 1998 Apr;18(2):134-9 - PubMed
28. Gastroenterology. 1994 Nov;107(5):1514-8 - PubMed
29. Gut. 2001 Sep;49(3):436-40 - PubMed
30. Gastroenterology. 1998 Jul;115(1):177-81 - PubMed
31. Liver Transpl. 2003 Mar;9(3):228-35 - PubMed
32. J Hepatol. 2006 Apr;44(4):717-22 - PubMed
33. Int Urol Nephrol. 2004;36(3):433-5 - PubMed
34. J Hepatol. 2006;44(1 Suppl):S28-34 - PubMed
35. Am J Pathol. 1992 Jun;140(6):1295-308 - PubMed
36. Transplantation. 1997 Jan 15;63(1):158-60 - PubMed
37. MMWR Morb Mortal Wkly Rep. 2006 May 12;55(18):509-11 - PubMed
38. World J Gastroenterol. 2007 May 7;13(17):2436-41 - PubMed
39. J Gastroenterol Hepatol. 1998 Nov;13(11):1133-7 - PubMed
40. Hum Pathol. 2006 Oct;37(10):1344-9 - PubMed
41. Gut. 1992 Oct;33(10):1390-6 - PubMed

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